Lester Holt

Egghead?

Nerdy?

The couple made a home just outside Boston.

In a few years, a baby girl arrived into their hectic lives.

Autumn took it in stride.

The new mother was becoming a sought-after specialist in neurological ailments in women.

Because of her expertise, she was interviewed for an educational video distributed by the Discovery Channel.

But Autumn was growing frustrated with Boston, and professionally, she felt as though she'd crested there.

That's when Pittsburgh loomed into view.

In 2011, the University of Pittsburgh and its renowned Sister Medical Center offered an ideal career move.

For Bob, a new research lab.

For Autumn, a chance to head her own department.

But still something was gnawing at her, a kind of emotional vacuum.

She wanted to have another child.

By now in her early 40s, she was taking fertility treatments, hormone injections, but nothing was happening.

Was it really eating away at her?

That she wasn't getting pregnant?

Time was going by.

Looking back, her mom Lois recognized some worrisome signs, changes in her daughter.

Then, in early 2013, the couple tried a new approach to the baby problem.