Lorenzo Leggio

Got it.

We have examples.

For example, we have actually three medications approved by the FDA for people with alcohol use disorder.

Natrexone, Acamproset, Desofram.

We have two more medications that are called Pyramid and Gabapentin.

Sometimes the people, clinicians use off-label with the consent of the patient.

These medications are endorsed by the American Psychiatric Association as a second-line treatment.

And that's an example of off-label use.

Yeah, you are absolutely right, David.

So we actually, as a society, as a community, as a clinical community, we dramatically undertreat the people with alcohol use disorder.

To give you, to make an analogy,

So in the United States, 2% of people with alcohol disorder receive a prescription for an FDA-approved medication, naltrexone, acamprosate, or disulfiram.

As a comparison, 85% of people with diabetes receive the prescription for a medication approved for diabetes.

It would be unacceptable.

You're absolutely right.

And so what are the reasons?

I mean, there are many reasons.

People tend to be ashamed or not even recognize that their alcohol drinking is problematic.

So many people don't seek treatment.

But also many clinicians are not trained to identify, screen, diagnose, and treat people with alcohol use disorder.