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Louisa Nicola

👤 Person
618 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

dramatically understudied when it comes to these diseases in academic medicine. We won't go into that because I have beef with Charles Darwin, so we won't go into that. But I really wanted to highlight that and the importance of ladies in their 50s, in their 60s who are leading up to that stage, how fundamental exercise really is.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

That's not too aggressive at all.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

That's not too aggressive at all.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

That's not too aggressive at all.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

That's a true statement from me.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

That's a true statement from me.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

That's a true statement from me.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

Yes, and when I said the statistic two out of three Alzheimer's cases are female, we still don't know why, because women are understudied in science. So we need greater advocacy for understanding that. Okay. We need to understand why that is, but we do have a rudimentary understanding and it does come down to estrogen.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

Yes, and when I said the statistic two out of three Alzheimer's cases are female, we still don't know why, because women are understudied in science. So we need greater advocacy for understanding that. Okay. We need to understand why that is, but we do have a rudimentary understanding and it does come down to estrogen.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

Yes, and when I said the statistic two out of three Alzheimer's cases are female, we still don't know why, because women are understudied in science. So we need greater advocacy for understanding that. Okay. We need to understand why that is, but we do have a rudimentary understanding and it does come down to estrogen.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

So let's go back to the physiology lesson and we can understand why the heart plays a really important role. And this actually comes from Ben Levine, who's a sports cardiologist. And he's done absolutely foundational work when it comes to the structure of the heart. So what happens, just like the brain, as we age... the brain changes. It ages too.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

So let's go back to the physiology lesson and we can understand why the heart plays a really important role. And this actually comes from Ben Levine, who's a sports cardiologist. And he's done absolutely foundational work when it comes to the structure of the heart. So what happens, just like the brain, as we age... the brain changes. It ages too.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

So let's go back to the physiology lesson and we can understand why the heart plays a really important role. And this actually comes from Ben Levine, who's a sports cardiologist. And he's done absolutely foundational work when it comes to the structure of the heart. So what happens, just like the brain, as we age... the brain changes. It ages too.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

We see a decrease in our cell size because as we age, we get a decrease in cell size. It's just part of the natural brain aging process. You're never going to get to age 100 and see thicker cortical areas in your brain as opposed to a 20-year-old. So we just know that. The heart ages too. So as we get older, we get stiffening of the arteries.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

We see a decrease in our cell size because as we age, we get a decrease in cell size. It's just part of the natural brain aging process. You're never going to get to age 100 and see thicker cortical areas in your brain as opposed to a 20-year-old. So we just know that. The heart ages too. So as we get older, we get stiffening of the arteries.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

We see a decrease in our cell size because as we age, we get a decrease in cell size. It's just part of the natural brain aging process. You're never going to get to age 100 and see thicker cortical areas in your brain as opposed to a 20-year-old. So we just know that. The heart ages too. So as we get older, we get stiffening of the arteries.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

The arteries are big pumps that come out of the aorta that pump your entire body of blood. They get stiffer as we age. What also happens is we have a left ventricle of the heart. We've got a right ventricle. The right ventricle pumps blood to the lungs. The left pumps blood to your entire body, the organs, the muscles. that left ventricle over time gets stiffer.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

The arteries are big pumps that come out of the aorta that pump your entire body of blood. They get stiffer as we age. What also happens is we have a left ventricle of the heart. We've got a right ventricle. The right ventricle pumps blood to the lungs. The left pumps blood to your entire body, the organs, the muscles. that left ventricle over time gets stiffer.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

The arteries are big pumps that come out of the aorta that pump your entire body of blood. They get stiffer as we age. What also happens is we have a left ventricle of the heart. We've got a right ventricle. The right ventricle pumps blood to the lungs. The left pumps blood to your entire body, the organs, the muscles. that left ventricle over time gets stiffer.

Dhru Purohit Show
Neurophysiologist Shares Top 3 Drivers of Alzheimer’s Disease, How To Reduce Your Risk of Cognitive Decline At Any Age, and How to Build a Super-Brain with Louisa Nicola (Rebroadcast)

So we get something called left ventricular hypertrophy. So the walls of the left ventricle thicken as we age. Now, Ben Levine was really, he's wonderful. He did a study where he took 53 50-year-olds. He subjected them over the course of two years to maximal aerobic exercise programs. I think it was around three to four hours per week.