Luke O'Neill
speaker
4,222 appearances
22 recordings
2 series
first heard Apr 2026
last heard 10 Sep
Luke O'Neill’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 22 in all, peaking in Jul 2026 with 6.
Appearances
And they're quite complicated, actually.
There's a few different components in them.
First of all, they have things called mastoperins in the wasp sting.
Mastoperins.
Now, the words will get tricky.
These are peptides.
And, of course, peptides are very trendy at the moment, given things like ozempic.
But these are made of bits of protein, mastoperins.
They're called mastoperins because they activate things called mast cells.
When the wasp sting goes in, the mastoperin latches onto these things called mast cells.
And mast cells are part of your immune system.
And the mast cells release histamine.
Now, there you have it.
The histamine comes out.
That's a key component in your body.
And the histamine makes your nerves tingle, so you feel the pain.
The histamine also opens up blood vessels, so more blood rushes in, and you get the inflammatory process, which I work on, and it goes red, and it's sore, and the mastoparins are activating the mast cells.
to do these things like release histamine.
You also get IgE latching onto the mast cells, causing them to release the histamine.
So the first thing we see then is mast cell involvement.
Showing 41–60 of 4,222 · page 3 of 212
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