Manolis Kellis

It probably means that they're sampled from the same underlying distribution,

But he was probably a rare combination of extremes in addition to these common variants.

So you can basically interpret your kid's variation, for example, as, well, of course, they're going to be some kind of sampled from the average of the parents with some kind of deviation according to the specific combination of rare variants that they have inherited.

So, given all that, the possibilities are endless as to sort of where you should be, but you should always interpret that with, well, it's probably an alignment of nature and nurture.

And the nature has both the common variants that are acting kind of like the law of large numbers and the rare variants that are acting more in a Mendelian fashion.

And then you layer in the nurture, which again, in everyday action we make, we shape our future environment.

But the genetics we inherit are shaping the future environment of not only us, but also our children.

So there's this weird nature-nurture interplay and self-reinforcement where you're kind of shaping your own environment, but you're also shaping the environment of your kids.

And your kids are going to be born in the context of your environment that you've shaped, but also with a bag of genetic variants that they have inherited.

And there's just so much complexity associated with that.

When we start blaming something on nature, it might just be nurture.

It might just be that, well, yes, they inherited the genes from the parents, but they also were shaped by the same environment.

So it's very, very hard to untangle the two.

And you should always realize that nature can influence nurture, nurture can influence nature, or at least be correlated with and predictive of, and so on and so forth.

Is it a totally ridiculous way to think about-?

No, not at all.

So I would say evolutionarily, we are a very slow evolving species.

Basically, the generations of humans are a terrible way to do selection.

What you need is processes that allow you to do selection in a smaller, tighter loop.

Yeah.