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Matt Kaplan

๐Ÿ‘ค Speaker
569 total appearances

Appearances Over Time

Podcast Appearances

StarTalk Radio
Told You So! with Matt Kaplan

And that's because Ferdinando de' Medici.

StarTalk Radio
Told You So! with Matt Kaplan

And by the way, the de' Medici by that time, de' Medici family by that time had already supplied two Queens to France and four

StarTalk Radio
Told You So! with Matt Kaplan

That's right.

StarTalk Radio
Told You So! with Matt Kaplan

So these folks were really powerful, had ensured that Galileo did not end up tortured.

StarTalk Radio
Told You So! with Matt Kaplan

So there was a lot of political disruption that occurred to protect Galileo and make sure that, you know, he didn't get burned at the stake.

StarTalk Radio
Told You So! with Matt Kaplan

So this is Kati Kariko, and Kati Kariko was working on messenger RNA back in the 90s.

StarTalk Radio
Told You So! with Matt Kaplan

And messenger RNA, she worked out, you could effectively program messenger RNA to produce any protein you damn well pleased in the lab.

StarTalk Radio
Told You So! with Matt Kaplan

And that had tremendous potential because if you could program messenger RNA and inject it into somebody and have it start producing proteins of a specific type, that could be really useful for all kinds of medicines, particularly things like vaccines.

StarTalk Radio
Told You So! with Matt Kaplan

But the problem was, as Kati was working, every time the mRNA got injected inside an animal,

StarTalk Radio
Told You So! with Matt Kaplan

it would just fall apart.

StarTalk Radio
Told You So! with Matt Kaplan

And she could demonstrate that there was potential here, but she couldn't work out what the issue was.

StarTalk Radio
Told You So! with Matt Kaplan

And when she applied for grants, the grants were rejected because the narrative that existed in the academic community was messenger RNA isn't going anywhere.

StarTalk Radio
Told You So! with Matt Kaplan

It's not worth your time.

StarTalk Radio
Told You So! with Matt Kaplan

Even if the proposals were written well, even if the experiments were well thought out, she got nowhere as a result because in academia today, you are only as good as the money you bring into the university.

StarTalk Radio
Told You So! with Matt Kaplan

If you're not bringing in lots of resources from grants, the university takes a dim view and you slowly get pushed out.

StarTalk Radio
Told You So! with Matt Kaplan

Katsi was first demoted for exploring messenger RNA and not getting enough grants.

StarTalk Radio
Told You So! with Matt Kaplan

And then she was fired by the university because they felt she really was a waste of time.

StarTalk Radio
Told You So! with Matt Kaplan

She was threatened by the US government with deportation back to Hungary.

StarTalk Radio
Told You So! with Matt Kaplan

I mean, it's frustrating because ultimately we're very lucky that after 25 years of pain and suffering with all of this, she didn't just say, screw this.

StarTalk Radio
Told You So! with Matt Kaplan

I'm going to go become a dental hygienist or a florist or something.