Max Lugavere

That's very important.

You don't want to be obese.

Obesity increases your risk for hypertension.

It also increases your risk for insulin resistance and type two diabetes.

So you don't want to be obese.

There's actually an inverse correlation between

the size of your waist and total brain volume.

So as your waist expands, it seems that your brain shrinks.

The direction of causality isn't there.

It's just a correlation.

But nonetheless, visceral fat is strongly linked to insulin resistance and inflammation.

And the brain sits directly downwind of insulin resistance and inflammation, unfortunately.

Because I think they're looking for the cure in the wrong place.

They're trying to treat a condition that begins in the brain decades prior to the onset of symptoms.

And their target of approach is reducing amyloid in the brain.

And amyloid appears late, as we mentioned.

So, you know, by the time a person is diagnosed with Alzheimer's disease, glucose metabolism is already diminished by 50%.

So your brain is already desperately struggling to create energy by the time you, you know, receive that diagnosis.

And the buildup of amyloid plaque and these tau tangles, you know, the hallmark neuropathological

phenomena that is defining of the condition is already there in stark, to a stark degree, there's already typically widespread neuronal death.