Max Lugavere

Modern bread is loaded with refined grains, added sugars, industrial oils, and it is far removed from unadulterated whole grains.

Observational data links the consumption of whole grains to better health outcomes.

But most people today, when it comes to bread, commercial breads are consuming largely ultra processed foods.

If you're eating truly whole grain bread, I think that, you know, you're probably going to be fine.

But most bread today is not truly whole grain.

Yeah.

Even breads that are marketed as whole grain are like pulverized, like, you know, extruded grains that have the bran removed, have synthetic vitamins added after the fact and are essentially ultra processed foods.

Leaky gut might be involved.

We don't have, you know, solid evidence to say.

First of all, leaky gut is intestinal permeability.

So undue intestinal chronic, chronic and undue intestinal permeability.

That's what is sometimes referred colloquially as as leaky gut.

I can't say with certainty that leaky gut causes or intestinal permeability causes Alzheimer's disease, but leaky gut intestinal permeability can drive inflammation.

And the brain sits downwind of inflammatory processes in the body.

And the gut is a huge mediator of inflammation because it's your body's largest interface with the environment.

So when you have excessive intestinal permeability,

You're allowing compounds to enter circulation that shouldn't be there.

The compounds that are, I think, most risky are components of gram-negative bacteria that live in the large intestine called lipopolysaccharide, also known as endotoxin, and can be profoundly inflammatory when allowed to enter circulation.

And typically, that doesn't occur.

But when you have an excessively leaky gut, which can be driven by