Meg Tirrell

We've heard from people sort of anecdotally saying like, I felt like I hadn't eaten in a year.

And she was like, I guess I hadn't, you know, because she'd been taking this medicine and her appetite was so suppressed, but just revved back up.

But I think it can be different for everybody.

I mean, the studies show that the majority of people, if you stop taking one of these drugs, they do regain at least some of the weight.

But not everybody does.

People are different.

And so I think that's really fascinating.

And it probably also has to do with

what happened when you were on the drug in terms of what changes you made in your own life?

I mean, did you start cooking differently?

Did you start exercising more?

Find something you enjoy and that you could keep doing.

So I think those are some of the big questions.

I also think, as you noted, a big reason people would stop is, I mean, the cost was so high.

And it still is really high in a lot of ways, but it's also come down dramatically for some of these options.

And I think a hope is that it'll enable people who are benefiting from the medicines to stay on them for longer.

Well, I think this is so interesting because a lot of those things people thought were just completely related to weight loss.

You know, hey, if you lose 20% of your body weight, of course you're going to have a lower risk of having a heart attack or a stroke.

And so I remember they did this huge cardiovascular outcomes trial for Wegovy, which is the GLP-1 made by Novo Nordisk.

It came out a couple of years ago, 2024.