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Michael Levin

๐Ÿ‘ค Speaker
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4080 total appearances
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Podcast Appearances

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

And so what you can do is you can do that in many different ways.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

One way is with drugs that target ion channels to say, and so you pick these drugs and you say, okay, I'm going to do it so that instead of this one head, one tail electrical pattern, you have a two-headed pattern, right?

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

You're just editing the electrical information in the network.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

When you do that, guess what the cells build?

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

They build a two-headed worm.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

And the coolest thing about it, now no genetic changes, so we haven't touched the genome.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

The genome is totally wild type.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

But the amazing thing about it is that when you take these two-headed animals and you cut them into pieces again,

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Some of those pieces will continue to make two-headed animals.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

So that information, that memory, that electrical circuit, not only does it hold the information for how many heads, not only does it use that information to tell the cells what to do to regenerate, but it stores it.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Once you've reset it, it keeps.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

And we can go back.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

We can take a two-headed animal and put it back to one-headed.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

So there's a couple of interesting things here that have implications for understanding of genomes and things like that.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Imagine I take this two-headed animal.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Oh, and by the way, when they reproduce, when they tear themselves in half, you still get two-headed animals.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

So imagine I take them and I throw them in the Charles River over here.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

So 100 years later, some scientists come along and they scoop up some samples and they go, oh, there's a single-headed form and a two-headed form.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Wow, a speciation event.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Cool.