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Michael Levin

๐Ÿ‘ค Speaker
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4080 total appearances
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Podcast Appearances

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

You can have other information in there and it's reprogrammable by us, by bacteria, by various parasites, probably things like that.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

The other amazing thing about these planarias, think about this.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Most animals, when we get a mutation in our bodies, our children don't inherit it, right?

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

So you could go on, you could run around for 50, 60 years getting mutations.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Your children don't have those mutations because we go through the egg stage.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Planaria tear themselves in half, and that's how they reproduce.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

So for 400 million years, they keep every mutation that they've had that doesn't kill the cell that it's in.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

So when you look at these planaria, their bodies are what's called mixoploid, meaning that every cell might have a different number of chromosomes.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

They look like a tumor.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

If you look at the...

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

The genome is an incredible mess because they accumulate all this stuff.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

And yet, their body structure is... They are the best regenerators on the planet.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Their anatomy is rock solid, even though their genome is all kinds of crap.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

So this is kind of a scandal, right?

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

That, you know, when we learn...

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

What are genomes?

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Genomes determine your body.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Why does the animal with the worst genome have the best anatomical control, the most cancer-resistant, the most regenerative?

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

Really, we're just beginning to start to understand this relationship between the genomically determined hardware.

Lex Fridman Podcast
#325 โ€“ Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots

By the way, just as of a couple of months ago, I think I now somewhat understand why this is, but it's really a major puzzle.