Michael Regilio
speaker
2,071 appearances
9 recordings
1 series
first heard Nov 2024
last heard 12 Jul
Michael Regilio’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Jul 2026 with 1.
Appearances
Yeah. The best part of waking up is having Folgers ground into the back of your head. Does have a certain ring to it, but no, it's not coffee, but cream, a caffeine cream. Okay. Other new treatments include platelet-rich plasma in which a person's own blood cells are injected into their scalp.
Yeah. Okay. So here we go with the stuff with side effects. The active ingredient in Rogaine is minoxidil. Minoxidil was developed to treat hypertension. Actually, it was developed to cure ulcers, but it didn't work for that. But it did lower blood pressure, so it was approved for blood pressure. But it ended up growing hair on people's heads, so they just switched it to that.
Yeah, pretty much. Minoxidil works by increasing blood flow to the scalp and everywhere else. As one would expect when taking an ulcer slash hypertension slash hair regrowth slash dessert topping medication, there are side effects like ankle swelling, headaches, and dizziness.
Other side effects include reduction in libido, reductions in overall feelings of well-being, and increases of male breast tissue.
Yeah, it's not always an easy choice. Plus, the hair growth is only effective as long as you're on minoxidil. So it's either take it for life or stop at some point and watch your hair fall back out. So minoxidil might not be for you. There's always finasteride. That's the drug in all the other big brands like Propecia. I have heard of that one.
The history of finasteride turns out to be an interesting one as well. It all started with the study of a group of intersex children in the Caribbean who were raised as girls, then at puberty grew external male sex organs.
Okay, that's not quite what I'm telling you. What I am telling you is that these individuals who appear to be female at birth and are raised as girls grow penises at around 12 years of age, and usually they'll switch from identifying as girls to identifying as boys. They're called guevedoses, which in Spanish means penis at 12.
Of course, you're right. And it is super interesting. And it does, by the way, have to do with hair regrowth. incredibly rare everywhere on earth except one small village in the Dominican Republic called Salinas. In Salinas, one out of 90 boys are born with this condition.
Before any of this was understood, one would have been justified in saying that in Salinas, one out of 90 girls born turn into boys at around 12 years of age, which is what people used to think.
As we know, at conception, a person destined to be a girl has a set of X chromosomes, while a person destined to become a boy has an X and a Y. Then, at around eight weeks after conception, the sex hormones kick in. If you're genetically male, the Y chromosome instructs your gonads to become testicles and sends testosterone to something called the tubercle.
And the testosterone is converted into... DHT. Ah, yes, DHT. I'm starting to see the connection here. And the DHT turns the tubercle into a penis. And Guevedo says the reason they don't have what we would recognize as a penis when they are born is because they are deficient in an enzyme, which we mentioned earlier, called 5-alpha reductase, which converts testosterone into DHT.
But at puberty, when genetic males get a second blast of testosterone, they finish growing the penis. This is why people believed that these girls were growing a penis at 12.
You're right. It does open up a whole host of new questions, and I'm sure we could do a whole episode here. So I'll just hit you with this little fact that I thought was so interesting. Despite being raised as girls, most Cueva Doses grow up to be heterosexual males. So much for the people who think you can turn someone gay or turn someone straight. Sorry, gay conversion advocates.
Yes, right now. It's because Guavidoses had smaller prostates due to their genetic disorder. Scientists used what they learned about Guavidoses to help people with enlarged prostates. It was in studying Guavidoses that scientists were able to develop Finasteride.
Turns out that taking finasteride grows hair. That's the hair growth industry's motto. Someone will accidentally invent something for us. How effective is this? It can increase hair growth by 20%. It can reduce hair loss in 90% of people. It increases hair thickness by 20 to 30%.
It kind of has the opposite effect because it can also cause erectile dysfunction, suicidal thoughts, depression, and low sex drive.
But those are just possible side effects. For lots of people, these options work out great, especially when done in conjunction with other stuff like microneedling.
Guess what? Collagen is all the rage. Influencers and celebrities are downing collagen drinks like crazy. Collagen drinkers claim collagen gives them healthier, younger-looking skin, hair, and nails. And since the natural collagen our bodies make provides support for these very tissues, these claims actually seem plausible.
Collagen is a protein. It's the most common protein found in the body. It is in skin, hair, nails, bones, cartilage, and tendons. It works with other stuff in our body to give our skin its moisture and elasticity. It's also partly what hair and nails are made of. Collagen also helps wounds to heal.
Okay, well, our bodies do produce collagen using foods like bone broth, meat, and fish, but old man time, sun exposure, smoking, and drinking decreases the amount we produce.
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