Mike Israetel
speaker
1,094 appearances
5 recordings
5 series
first heard Dec 2024
last heard May 2025
Mike Israetel’s voice in public audio — every appearance, attributed to the second.
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Appearances
Now that they've reduced those foods, but they haven't eaten any better foods, they're like at rest. decent risk of vitamin mineral deficiencies and not getting enough D vitamins and B vitamins and calcium and all the way down the line, if they're going to like shrink down and you're going to be like, Debbie, how are you? She's like, good, good. You're like holidays treated you well.
She's like, yeah. You're like, Debbie, we haven't known each other a long time. Are you sick? Is something going on? I want to send you flowers or something. She's like, no, I'm out on Zempik. I'm feeling great. You look her up and down. You're like, okay. You just walk off. Parts of you are disappearing and not in a fun way. And bags under her eyes, her skin looks really pale.
She's just under nutrition. That's what we call it. And so folks like that suffer greatly from that situation, which is simply remediated by eating most of your diet as lean meats, veggies, fruits, whole grains, healthy fats.
If you do that, then as you reduce the amount of that food, it's still so vitamin and mineral and nutrient dense that you're just going to be a leaner, more awesome version of yourself. The second problem is protein. So people don't eat enough protein when they You know, take Ozempic and they just eat mostly junk food. Now they eat less junk food. Now they're eating even less protein.
Then they can become what's called hypoproteinemic, which means they just don't have enough protein for normal body functions, which means they start to take protein from the parts of your body that need it the least for survival. So it doesn't happen like this exactly, but you could see it blown out as like your body's like, all right, everyone line up.
We need amino acids, which are the building blocks of protein. We don't have enough. Who's willing to give them up? Heart? Heart's like, dude, I'm pumping blood. We'll die if I don't have enough muscle. Heart, you're good. Get out of here. Brain? I'm thinking all of these solutions and ideas. Okay, brain, get out of here. Liver? Are you kidding me? We do all the detox. Okay, liver, get out of here.
hey, skeletal muscle, what are you up to? And it's like hoarding amino acids. I'm good. Do you need all those? Like, well, yeah, I got to move us around. Like, where are we moving? We got elephants chasing us down. Give me up some of that. So what ends up happening is because muscle, skeletal muscle isn't critical to your survival until you have very low levels of it.
These people just lose lots and lots of muscle mass, which gets looking like a zempic face and a zempic butt, which again, just makes you look sick. It increases your risk of all kinds of diseases. It does not make you more mobile. It barely makes you more attractive. Can you imagine a guy looking at a girl like,
man she's really hot like oh why do you like her so much like she looks like she's dying of illness like what that's not anyone says that and so all of a sudden the poor nutrition is bad because now you have too little nutrition from taking these drugs and doing nothing about it the insufficient protein is real bad but you also said something which i think was awesome point number three they don't resistance train they don't lift weights they don't exercise ozempic gives you such a huge anorectic response it drives your hunger down so much
you're likely to cut your calories by a substantial amount. And that's all hunky-dory, but that means the catabolic muscle breakdown drive in your body just escalated a ton. It's a formula for muscle loss. How do you prevent that? Well, you definitely have to have enough nutrition. We covered that. Enough protein. We covered that. Lifting weights. There is an argument. I'm not endorsing it.
There is an argument for every prescription that a doctor writes in America for the next several years of these anorectic drugs to come co-prescribed with go-resistance train. Because, and Dr. Lyon probably told you this extensively, skeletal muscle is an incredibly health-promoting tissue. You don't want little of it. You want plenty of it.
And if you lose weight the bad way and you don't resistance train, the signal for muscle loss is profound. The signal for, hey, regain some muscle and keep it on your body just really doesn't come through. So you just lose a bunch. But if you resistance train while eating a healthy diet, while getting enough protein, while taking these drugs, it's the
friggin miracle cure out here, you're going to re architect your body, you're going to functionally appear, feel, look and metabolically be like 10 years younger after losing 25 pounds of weight, because you'll gain something like you did five or 10 pounds of muscle, lose a load of fat is just as hugely enormous thing.
So the real problem to me with those folks that are less than 30 pounds overweight that they're using the drugs, isn't that they're like taking a shortcut, or it's the easy way out. I mean, like, like, The shortcuts are there for a reason. Like we want to take a shortcut. Some of you getting on a flight of JFK to go to, you know, Dubai or something.
And someone's like, you know, you could swim to Dubai. You're like, what the hell is wrong with you? I guess hypothetically, if I had a raft to rest on all the time, sure. It's just going to be faster. Like cheater, you know, also pours carbon dioxide in the environment. When the plane turns on, you're a bad person too. But like these shortcuts are seen as normal.
The drugs here are just an empowerment tool. That problem I have no, there's no problem with at all. But the fact that these people just kind of willy nilly the thing and they don't look at their healthy food intake, their protein consumption and their resistance training, they run into problems.
And the only reason fatter people don't run into problems is because they have so much excess musculary from carrying their body fat around. They just can't lose as much muscle relative to their size as everyone else can. And so, yeah, they still lose muscle. Oh, my God. But but.
and also because what's low calories for them is a higher number than it is for folks that weigh, weigh less, then also don't risk the under nutrition part nearly as much. And if they don't resistance train, but they just kind of walk around, it's pretty good resistance training for their legs.
They don't pay as much of approximate cost, but if those fatter people just kept losing weight, they pay all those downsides. So yeah, long story short, sorry for the giant rant, but these drugs are awesome and amazing. You don't have to take them, but they're an excellent option, but they're even more excellent by a huge factor.
If you combine them with healthy eating, higher protein intake and resistance training. And that's to me, the big kicker here is it's not drugs versus lifestyle. It's a teamwork effort and everyone can contribute. Drugs can contribute, though not necessary. Lifestyle can contribute and it's a little bit more necessary and just has a huge yield on everything. So that's kind of how I see the space.
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