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Nate Hagens

πŸ‘€ Speaker
3215 total appearances

Appearances Over Time

Podcast Appearances

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

The cell enters one branch after that fork, and then that branch forks again.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

At each fork, some of what was previously possible to that cell closes off.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

By the time it reaches the bottom of a particular valley, it is now committed to being, for instance, a heart cell.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

It will never again be a stem cell.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

nor will it become any other type of cell, at least not without extraordinary intervention.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

The valleys there are not all the same depth or size.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

Some are deep and have very steep walls.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

And once a cell enters, it stays because the constraints to leave are quite strong.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

Some valleys are quite shallow.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

A small perturbation or some chemical signal or a mutation might push the cell out and into a neighboring valley.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

And the ridges between those valleys also vary in height.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

Some transitions between cell states are relatively easy.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

Others would require enormous energy or very specific conditions that rarely occur naturally.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

I think this way of looking at a situation with valleys and ridges and mountains is useful because, you guessed it, I think it maps directly onto human civilizational futures.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

When we imagine and discuss and work towards various futures,

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

We're not choosing from a list of possible futures the way you would choose from a Chinese restaurant menu where everything is equally available and the only question is your preference.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

We're also not sitting at the top of a series of rolling hills and valleys like our imagined cell.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

We're already rolling through a moving landscape with a shifting topography and some futures

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

I would argue most futures are downhill from where we currently are.

The Great Simplification with Nate Hagens
How to Think About the Future (Part 3): Uphill Futures in a Downhill World | Frankly 145

Some are uphill, and by downhill I mean the path of least resistance.