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Nick Lane

👤 Person
795 total appearances

Appearances Over Time

Podcast Appearances

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

And you've got tens of thousands of copies.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

Sometimes the very largest one have 700,000 or 800,000 copies of their complete genome.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

The energy requirements for copying and expressing all of those genomes are colossal.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

What we have with an endosymbiosis, we still have extreme polyploidy, but we've whittled away all the genes that you don't need.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

So a symbiosis is based on effectively complementarity, that you've got a symbiont that's doing something for the host cell and the host cell is taking something or giving something back to the endosymbiosis.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

So it's a kind of a relationship which is based on mutual needs.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

One of them becomes much smaller and that allows the other one to become much larger.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

So a symbiosis will do it.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

Now, there could be multiple ways of having a symbiosis, but there's no examples on it.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

All of these examples of very large bacteria, and they all have extreme polyploidy.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

None of them have come up with a complex trafficking network where you effectively take things in and you ship it over there.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

There's just not enough genetic space to do that.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

I mean, a couple of things I'd say.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

Number one, there's a thing called Orgel's second rule, which is that evolution is cleverer than you are.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

So, yeah, of course, I cannot say that there's no other way that it could possibly happen.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

But it's also hand-waving to say, oh, you know, evolution's so clever, the universe is so big, there's got to be another way that it can happen.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

Okay, you know, engage your brain and tell me here's how it's going to work.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

Because I cannot say it's the only way it could possibly happen.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

Right.

Dwarkesh Podcast
Nick Lane – Life as we know it is chemically inevitable

But what I've said is that wet rocky planets are common.