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Nick Lane

๐Ÿ‘ค Speaker
795 total appearances

Appearances Over Time

Podcast Appearances

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

If you were a free-living bacterium living out there in the wild with a population of a million, and now you shelter inside another cell, and it's a small cell, now you've got a population of five.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

Yeah.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

I think they had no need for it.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

So what they do is lateral gene transfer is basically you pick up random bits of DNA from the environment.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

It can be a bit more sinister than that.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

You can kill the cell next to you and take its DNA and load that in.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

That does happen.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

But for the most part, you pick up bits of DNA from the environment, usually small pieces, usually kind of one gene's worth or something.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And you'd only do that if you're a bit stressed.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

If things aren't going well for you, you will then pick up bits of DNA, bind it into your genome and hope for the best.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

I guess for most critters, most of the time is not going to work.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

But for one of them, it does.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And then they will take over.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And so it kind of speeds up adaptation to a changing environment.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

So why are they only using one gene?

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

There's two ways of seeing this.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

You've got a bacterial-sized genome.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

It's pretty small.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

You're going to replicate faster if you keep that genome small.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

It's a kind of a disadvantage to have a big, unwieldy genome.