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Nick Norwitz

๐Ÿ‘ค Speaker
1350 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

They might have been eating a standard American diet, might not have been living a healthy lifestyle during which they could have had plaque accumulation. You know, just because you adopt a healthy lifestyle doesn't erase decades of living another lifestyle. So it could just be a phenomenon of You know, their prior diet, their prior exposure, their prior lifestyle led to plaque being there.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

They might have been eating a standard American diet, might not have been living a healthy lifestyle during which they could have had plaque accumulation. You know, just because you adopt a healthy lifestyle doesn't erase decades of living another lifestyle. So it could just be a phenomenon of You know, their prior diet, their prior exposure, their prior lifestyle led to plaque being there.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

They might have been eating a standard American diet, might not have been living a healthy lifestyle during which they could have had plaque accumulation. You know, just because you adopt a healthy lifestyle doesn't erase decades of living another lifestyle. So it could just be a phenomenon of You know, their prior diet, their prior exposure, their prior lifestyle led to plaque being there.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

And then the change of diet didn't just make the plaque suddenly vanish. So there was like a you could say a chink in the blood vessel armor, so to speak. And that, you know, seed preexisted as they were going on to this this trial. So I think that's probably the most likely phenomenon. There could be other phenomenon as well. I mean, there could be genetic contributions, for example.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

And then the change of diet didn't just make the plaque suddenly vanish. So there was like a you could say a chink in the blood vessel armor, so to speak. And that, you know, seed preexisted as they were going on to this this trial. So I think that's probably the most likely phenomenon. There could be other phenomenon as well. I mean, there could be genetic contributions, for example.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

And then the change of diet didn't just make the plaque suddenly vanish. So there was like a you could say a chink in the blood vessel armor, so to speak. And that, you know, seed preexisted as they were going on to this this trial. So I think that's probably the most likely phenomenon. There could be other phenomenon as well. I mean, there could be genetic contributions, for example.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

I guess we'll never know for certain, but I would say the most likely explanation is that people spent 50 years living another way. Probably that contributed to life progression. It's far more likely than blaming it on a few years of a ketogenic diet.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

I guess we'll never know for certain, but I would say the most likely explanation is that people spent 50 years living another way. Probably that contributed to life progression. It's far more likely than blaming it on a few years of a ketogenic diet.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

I guess we'll never know for certain, but I would say the most likely explanation is that people spent 50 years living another way. Probably that contributed to life progression. It's far more likely than blaming it on a few years of a ketogenic diet.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

What I would say is, you know, we have 100 people in this study. Actually, 100 people that enrolled in 100% retention. So no dropouts, which is actually pretty stunning. Just, you know, props to the participants. That's remarkable. But We didn't do a deep dive into every single lifestyle factor that every participant had. That was beyond the scope of the study.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

What I would say is, you know, we have 100 people in this study. Actually, 100 people that enrolled in 100% retention. So no dropouts, which is actually pretty stunning. Just, you know, props to the participants. That's remarkable. But We didn't do a deep dive into every single lifestyle factor that every participant had. That was beyond the scope of the study.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

What I would say is, you know, we have 100 people in this study. Actually, 100 people that enrolled in 100% retention. So no dropouts, which is actually pretty stunning. Just, you know, props to the participants. That's remarkable. But We didn't do a deep dive into every single lifestyle factor that every participant had. That was beyond the scope of the study.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

So I'll just talk in generalities about what could contribute to heart disease progression. And I think living a lifestyle that leads to insulin resistance, having overweight or obesity, prediabetes or diabetes at any point in your lifetime, smoking, obviously, various genetic factors, all could contribute to heart disease progression. So...

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

So I'll just talk in generalities about what could contribute to heart disease progression. And I think living a lifestyle that leads to insulin resistance, having overweight or obesity, prediabetes or diabetes at any point in your lifetime, smoking, obviously, various genetic factors, all could contribute to heart disease progression. So...

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

So I'll just talk in generalities about what could contribute to heart disease progression. And I think living a lifestyle that leads to insulin resistance, having overweight or obesity, prediabetes or diabetes at any point in your lifetime, smoking, obviously, various genetic factors, all could contribute to heart disease progression. So...

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

You know, the boilerplate stuff, sedentary, not sleeping well, smoking, eating poorly. It's kind of boring, but the fact of the matter is those are the things that probably increase your risk for heart disease, particularly things having to do with insulin resistance.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

You know, the boilerplate stuff, sedentary, not sleeping well, smoking, eating poorly. It's kind of boring, but the fact of the matter is those are the things that probably increase your risk for heart disease, particularly things having to do with insulin resistance.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

You know, the boilerplate stuff, sedentary, not sleeping well, smoking, eating poorly. It's kind of boring, but the fact of the matter is those are the things that probably increase your risk for heart disease, particularly things having to do with insulin resistance.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

So if you look at large-scale population studies, like having type 2 diabetes, prediabetes, high insulin resistance score, like an LPIR or a HOMIR, is a very strong predictor for poor cardiovascular health.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

So if you look at large-scale population studies, like having type 2 diabetes, prediabetes, high insulin resistance score, like an LPIR or a HOMIR, is a very strong predictor for poor cardiovascular health.