Nicole Parton

Other contributing factors listed were drowning, coronary artery disease, and the effects of buprenorphine.

Buprenorphine is used to treat opioid use disorder.

The manner of death has been ruled an accident.

Matthew Perry went to his country club to play a game of pickleball with friends around 11 a.m.

Perry returned to his home after the game and was seen by his assistant who was leaving the house to run errands at 1.37 p.m.

At 4 o'clock p.m., the assistant returned to the home.

Investigator Jennifer Herzog says the assistant found Perry floating face down in the heated end of the pool.

The assistant jumped into the pool and moved him into a sitting position on the steps and called 911.

Paramedics responded, pulled Perry out of the pool and onto the grass and pronounced him dead on the scene at 4.17 p.m.

His stepfather, Keith Morrison, is listed as the informant, which means the Dateline host is who identified Perry to authorities.

Matthew Perry's autopsy report doesn't say how or when Perry used ketamine prior to his death, but the coroner ruled out the ketamine treatments he had a week and a half before his death because ketamine has a half-life of three to four hours or less.

The report notes at the high levels of ketamine found in his post-mortem blood specimens, the main lethal effects would be from both cardiovascular overstimulation and respiratory depression.

Drowning contributes due to the likelihood of submersion into the pool as he lapsed into unconsciousness.

The autopsy report noted Matthew Perry's history of chronic obstructive pulmonary disease, emphysema, and diabetes.

The report mentions Perry's past drug use, but notes Perry had reportedly been clean for 19 months.

The New York Post reports that in the autopsy report, a comment is made about Perry undergoing ketamine infusion therapy, most recently one and a half weeks before his death.

The report states ketamine treatments are for anxiety and depression, but ketamine in the system couldn't be from the infusion therapy.

Dr. Bankhole-Johnson, one of the leading neuroscientists and physicians in the field, tells the New York Post that ketamine in Perry's system is more likely from recreational use.

Matthew Perry wrote about the ketamine infusions he received at the Swiss clinic.

He explained in his memoir that ketamine, quote, has my name written all over it.