Noemi Fuentes-Polaños

So it's a little bit waste of time for clinical purpose to have a look of all of the genes, right?

That's correct.

So another way that adults cancer oncology also do is to have a look of the patterns.

It's called mutational signatures.

This is the way to have a look of the genome of the cancer and looking for patterns.

We every day, every month, we learn more genes need to be added to the list.

That's correct.

And I think the pediatrics can inform adults and adults can inform pediatrics from the cancer biology perspective.

Question to ask, I think, will always be with my cancer type and my family history.

Sometimes we miss to ask for the family history, especially in adults, that's really critical, in kids as well.

But in adults, there are clear patterns on the family history that points you towards you need to be tested.

It's always worth to ask, do you have an understanding if I have a high probability of having a genetic mutation in my germline genes or if I'm predisposed to this?

Because this could be relevant for their cancer, for their kids, for their relatives.

So I think the right question is, have you considered if I need to be tested for an underlying inherited condition?

Correct.

Something I want to highlight as a message is the age of diagnosis is critical because we know that early onset cancers, also in adults, are probably more associated to an underlying genetic predisposition.

So if someone has a cancer under the age of 40, that per se could be relevant information to estimate the probability of finding a genetic change.

But I wouldn't say that we have clearly, steadily identified a rise in pediatric onset ones.

So it's a bit later on in adulthood.

Thank you.