Norman Swan

So you found genetic counselling was important in terms of the family implication.

But my original question was about actionable, you know, changing treatment.

And does it give you any clue as to why the mutations occurred subsequent to the germline?

So in other words, what triggers this change into cancer?

For parents listening who may have children and may have children with cancer...

Is this strong enough evidence now for this to be standard of care?

A child gets cancer and you do a full genome on the child?

What about the interpretation?

My understanding is when you've done a full genome, it's not necessarily obvious what's going on.

And in some places you get a panel of experts going through the genome and saying, yeah, that's significant and that's not significant.

Is there a sort of downstream implication of this that it's not just like a high cholesterol?

So let's move to adults now.

Why would it be any different from adults?

I mean, this is a thing that has driven me nuts with oncologists is...

They might do a panel of maybe 300 genes on you if you've got cancer to look for what they call an actionable gene.

Or is there another gene going on that we can find a drug?

And I've often said to them, why wouldn't you do a full genome?

And they say, oh, it's cost and complexity.

But if it's true of children, why isn't it true of adults?

But it's not a waste of time if you amass that information and you see patterns in the community.