Paul Nuyujukian

So what we see are immediate changes to the activity of the remaining neurons.

That change in activity lasts for about

a few days to a week-ish.

And then what we see is that the behavior of the neurons returns back to what it was before the injury.

And the behavior also is restored.

And so the degree of neural loss that we are generating

the brain can recover from.

And that's very important to help us understand how humans might be recovering from their strokes as well.

Even though we don't, in many cases, as people recover completely because the degree of injury is so vast, it's very likely that the mechanisms are likely conserved.

So what we have found are signatures of brain activity that are conserved after recovery and altered during injury.

If that's true in people as well, then we could use these signatures to track and monitor and help treat the recovery from injuries like stroke.

The promise for studying single neurons, if we can measure enough of them simultaneously, is to carefully estimate and understand what the brain itself is doing in the setting of these diseases and injuries, as well as in the normal setting.

Because if we can track how injured or damaged the patient's brain is, then we can develop therapies using that measurement to sort of nudge us closer to where the normal state of the brain should be.

Yes.

The way medical devices work is that you just need one device to get across the finish line, to be approved, and to have a market, right, where it's economically viable.

Once that's in place...

Researchers have access to what's called off-label use.

And from there, we can very easily take these approved devices, explore other applications and other diseases at fractions of the cost.

That's exactly right.

And we can just use the same device for different brain diseases.