Paul Saladino

It's a synonym for lipopolysaccharide. Lipopolysaccharide is a component of a bacterial cell wall, a gram-negative bacterial cell wall. So when you feed a human pure sugar, the wrong type of bacteria overgrow. This is dysbiosis. You mess up the gut flora.

It's a synonym for lipopolysaccharide. Lipopolysaccharide is a component of a bacterial cell wall, a gram-negative bacterial cell wall. So when you feed a human pure sugar, the wrong type of bacteria overgrow. This is dysbiosis. You mess up the gut flora.

It's a synonym for lipopolysaccharide. Lipopolysaccharide is a component of a bacterial cell wall, a gram-negative bacterial cell wall. So when you feed a human pure sugar, the wrong type of bacteria overgrow. This is dysbiosis. You mess up the gut flora.

And that signaling of endotoxin, it binds to TLR4, which is toll-like receptor 4, and you get cytokines, TNF-alpha, IL-6, and others, which signal inflammation in the human body. And your body says, whoa, I've got an infection. But you don't have an infection. You just ate a bunch of sugar. And that causes you to become insulin resistant due to an inflammatory mechanism.

And that signaling of endotoxin, it binds to TLR4, which is toll-like receptor 4, and you get cytokines, TNF-alpha, IL-6, and others, which signal inflammation in the human body. And your body says, whoa, I've got an infection. But you don't have an infection. You just ate a bunch of sugar. And that causes you to become insulin resistant due to an inflammatory mechanism.

And that signaling of endotoxin, it binds to TLR4, which is toll-like receptor 4, and you get cytokines, TNF-alpha, IL-6, and others, which signal inflammation in the human body. And your body says, whoa, I've got an infection. But you don't have an infection. You just ate a bunch of sugar. And that causes you to become insulin resistant due to an inflammatory mechanism.

I think seed oils cause insulin resistance at an energy generation mechanism at a mitochondrial electron level. and sugar causes it at an inflammatory level due to dysbiosis in the gut. Those are two major pathways. And again, what have we done here? All I'm saying is don't eat processed food, guys.

I think seed oils cause insulin resistance at an energy generation mechanism at a mitochondrial electron level. and sugar causes it at an inflammatory level due to dysbiosis in the gut. Those are two major pathways. And again, what have we done here? All I'm saying is don't eat processed food, guys.

I think seed oils cause insulin resistance at an energy generation mechanism at a mitochondrial electron level. and sugar causes it at an inflammatory level due to dysbiosis in the gut. Those are two major pathways. And again, what have we done here? All I'm saying is don't eat processed food, guys.

Like, because if you eat single ingredient foods, meat and plants, fruits and vegetables and meat, you're not getting seed oils and you're not getting processed sugar. Problem solved. Humans get healthy. Diabetes fixed, obesity fixed, heart disease fixed, cancer mostly fixed. Like, that's so easy. But no. Global Energy Balance Network, Sean.

Like, because if you eat single ingredient foods, meat and plants, fruits and vegetables and meat, you're not getting seed oils and you're not getting processed sugar. Problem solved. Humans get healthy. Diabetes fixed, obesity fixed, heart disease fixed, cancer mostly fixed. Like, that's so easy. But no. Global Energy Balance Network, Sean.

Like, because if you eat single ingredient foods, meat and plants, fruits and vegetables and meat, you're not getting seed oils and you're not getting processed sugar. Problem solved. Humans get healthy. Diabetes fixed, obesity fixed, heart disease fixed, cancer mostly fixed. Like, that's so easy. But no. Global Energy Balance Network, Sean.

Just think about calories. Don't think about food quality. You can still do the Coca-Cola, you know? This is the problem here. It's all kind of connected, right? And because who gets paid, right? So yeah, humans, it's easy. And it's not that humans either need to eat rabbit food or food that's not palatable.

Just think about calories. Don't think about food quality. You can still do the Coca-Cola, you know? This is the problem here. It's all kind of connected, right? And because who gets paid, right? So yeah, humans, it's easy. And it's not that humans either need to eat rabbit food or food that's not palatable.

Just think about calories. Don't think about food quality. You can still do the Coca-Cola, you know? This is the problem here. It's all kind of connected, right? And because who gets paid, right? So yeah, humans, it's easy. And it's not that humans either need to eat rabbit food or food that's not palatable.

I mean, I gave you raw steak earlier because the Airbnb grill was garbage, but you know, I could have given you cooked steak, squash, and strawberries. That's not horrible. it's maybe not as dopaminergic and as addicting as a Big Mac or Skittles, but that's hardly depriving yourself of like good tasting food. So the answer is really simple.

I mean, I gave you raw steak earlier because the Airbnb grill was garbage, but you know, I could have given you cooked steak, squash, and strawberries. That's not horrible. it's maybe not as dopaminergic and as addicting as a Big Mac or Skittles, but that's hardly depriving yourself of like good tasting food. So the answer is really simple.

I mean, I gave you raw steak earlier because the Airbnb grill was garbage, but you know, I could have given you cooked steak, squash, and strawberries. That's not horrible. it's maybe not as dopaminergic and as addicting as a Big Mac or Skittles, but that's hardly depriving yourself of like good tasting food. So the answer is really simple.

The molecular mechanisms I think are important to explain so that people understand what's going on beneath the surface and why all this happens. But essentially what's happened is that in the last 150 years, all of these foods have come into the human food supply, the American food supply,

The molecular mechanisms I think are important to explain so that people understand what's going on beneath the surface and why all this happens. But essentially what's happened is that in the last 150 years, all of these foods have come into the human food supply, the American food supply,