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Paul Turek

👤 Person
716 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And there's also a mucus plug that exists for 28 days a month to prevent anything from going through because it's a hole into the woman's body and peritonitis is severe, right? And the cervical mucus thins and that's to let sperm through for two days a month. It's incredibly detailed, perfectly orchestrated system.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And there's also a mucus plug that exists for 28 days a month to prevent anything from going through because it's a hole into the woman's body and peritonitis is severe, right? And the cervical mucus thins and that's to let sperm through for two days a month. It's incredibly detailed, perfectly orchestrated system.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So it looks like the first round of sperm get through the cervix, get into the uterus, and they get demolished like a phalanx, like a Roman phalanx. And maybe a second round goes through and they get demolished and they're secreting the FCR receptor on the immunoglobulin because that's what antibodies bind to. So the female antibodies bind to that.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So it looks like the first round of sperm get through the cervix, get into the uterus, and they get demolished like a phalanx, like a Roman phalanx. And maybe a second round goes through and they get demolished and they're secreting the FCR receptor on the immunoglobulin because that's what antibodies bind to. So the female antibodies bind to that.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And we don't know how many phalanxes go through, but then it's like a run up the middle. And then eventually a couple of sperm or fourth make it and the immune system's deactivated and they get there. It's wild. And that can be measured now. And there's actually going to be an assay available to look at whether you're doing this.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And we don't know how many phalanxes go through, but then it's like a run up the middle. And then eventually a couple of sperm or fourth make it and the immune system's deactivated and they get there. It's wild. And that can be measured now. And there's actually going to be an assay available to look at whether you're doing this.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

They're calling it a sperm cycle, almost like ovulation, spermulation. But it's an hour and a half cycle when the phalanx is working, sperm are deactivating the immune system, and then maybe they don't. So there are jaculates, which is a group of sperm, some of which do this well and some of which don't. And that can be a whole reason for infertility.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

They're calling it a sperm cycle, almost like ovulation, spermulation. But it's an hour and a half cycle when the phalanx is working, sperm are deactivating the immune system, and then maybe they don't. So there are jaculates, which is a group of sperm, some of which do this well and some of which don't. And that can be a whole reason for infertility.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Yep. 100 to 500 get to the fallopian tube and one gets to the egg. Wow. Why do you need so many sperm? The classic answer used to give is they don't like to ask for directions. Men don't like to ask for directions, but this is probably why.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Yep. 100 to 500 get to the fallopian tube and one gets to the egg. Wow. Why do you need so many sperm? The classic answer used to give is they don't like to ask for directions. Men don't like to ask for directions, but this is probably why.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

It takes about 60 to 70 days. And it's a process called meiosis. So in a car assembly line, the Model T assembly, you know, mass produce, you want to all be the same. In meiosis, which is unlike mitosis, you want things to be different and to be a little easy peasy. So you get what's called recombination. And so that's the source of evolution.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

It takes about 60 to 70 days. And it's a process called meiosis. So in a car assembly line, the Model T assembly, you know, mass produce, you want to all be the same. In meiosis, which is unlike mitosis, you want things to be different and to be a little easy peasy. So you get what's called recombination. And so that's the source of evolution.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So the genes, the chromosomes blend in a different way and separate a different way. And through that process of a couple of those, you get half the number of chromosomes, which is required to join the other half.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So the genes, the chromosomes blend in a different way and separate a different way. And through that process of a couple of those, you get half the number of chromosomes, which is required to join the other half.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Correct. It's a loosey goosey.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Correct. It's a loosey goosey.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Five million eggs at conception, one million eggs at birth, and you basically ovulate a thousand in your lifetime. Okay. So by the time you're 45, you're out of eggs. You actually ovulate one a month, but you actually produce 10 a month. So you lose 10. For every one. Right. So a lot of waste.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Five million eggs at conception, one million eggs at birth, and you basically ovulate a thousand in your lifetime. Okay. So by the time you're 45, you're out of eggs. You actually ovulate one a month, but you actually produce 10 a month. So you lose 10. For every one. Right. So a lot of waste.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But they're stuck in a stage of perpetual space where they're just, you know, and they get older and they don't evolve really. And then they mature when they're asked to at that time.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But they're stuck in a stage of perpetual space where they're just, you know, and they get older and they don't evolve really. And then they mature when they're asked to at that time.