Peter Attia

Hey everyone, welcome to The Drive Podcast.

I'm your host, Peter Attia.

This podcast, my website, and my weekly newsletter all focus on the goal of translating the science of longevity into something accessible for everyone.

Our goal is to provide the best content in health and wellness, and we've established a great team of analysts to make this happen.

It is extremely important to me to provide all of this content without relying on paid ads.

To do this, our work is made entirely possible by our members, and in return, we offer exclusive member-only content and benefits above and beyond what is available for free.

If you want to take your knowledge of this space to the next level, it's our goal to ensure members get back much more than the price of a subscription.

If you want to learn more about the benefits of our premium membership, head over to peteratiamd.com forward slash subscribe.

My guest this week is Dom D'Agostino.

Dom is a neuroscientist and professor at the forefront of metabolic therapies, including ketogenic strategies, exogenous ketones, and hyperbaric oxygen.

In this episode, we discuss nutritional versus supplemental ketosis, clear definitions, thresholds for clinical ketosis, and practical ways to achieve it while keeping protein adequate.

Why the early transition into a ketogenic diet can be challenging and how electrolytes and ketone salts can smooth that on-ramp.

The growing landscape of exogenous ketones, the salts versus the esters, 1,3-butanediol, taste and insulin effects, and simple effective pairings such as caffeine, MCT, and alpha-GPC.

Ketogenic diets as metabolic therapy for cancer, especially glioblastoma.

the prospects for ketogenic diets in neurodegenerative diseases, including dementia and Alzheimer's disease specifically, hyperbaric oxygen chambers, Dom's recommended protocols, practical barriers, and the rigor of ongoing trials, when fasting and ketones shine as a situational tool for cognition, workload, travel, and inflammation, and the carnivore diet as a ketogenic variant and what it implies for certain autoimmune and metabolic conditions.

So without further delay, please enjoy my conversation with Dom D'Agostino.

Hey Dom, thank you for making the trip out to Austin.

It's, boy, it has been a long time since we've been in person.

I'm afraid to hazard a guess as to when, but I know you and my brother see each other a lot more and I'm always getting pictures of you visiting him and him visiting you.

Well, the same can be said for you.