The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
So another way to think about this is through the lens of the fibers that are involved.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
And again, these are terms we've used on the podcast before, but the goal of this podcast is to kind of tie this all together.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
So at lower intensities, you have these type one or slow twitch muscle fibers.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
And again, I think the term slow twitch, it does to some extent reflect the speed with which they twitch.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
But I think a more important way to think about them is they're slow to fatigue and they're more endurance based fibers.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
So again, at lower intensities, they're the ones that are doing all the work.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
very rich in mitochondria, deep red.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
They excel at oxidizing fat and they're very, very efficient.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
As the intensity increases, we have to start recruiting more of the type two fibers.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
These are fast twitch fibers, which again are more contractile in their force, but they are also fast to fatigue.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
They have less mitochondria and they're going to recruit and rely more heavily on glycolysis.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
that's happening outside the mitochondria.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
So initially, lactate, which again, kind of gets a bit of a bad rap, but again, we've done an entire podcast on this and we'll link to the podcasts on this topic.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
But the most important of these is definitely the one with George Brooks.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
Initially, the lactate gets recycled locally.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
So it's shuttled to neighboring type 1 fibers.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
It gets generated in a type 2 fiber, gets shuttled to a type 1 fiber, gets converted back into pyruvate,
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
And then the pyruvate goes into the mitochondria to produce more ATP.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
That's called the lactate shuttle.
The Peter Attia Drive
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
But again, these things are constrained by demand.