Peter Attia

30 milligrams per deciliter is about what a child is.

So we're born with relatively low levels of ApoB, and as we age, they just keep going up and up and up, which of course is one of the things that's driving cardiovascular disease is this rise in ApoB.

So the question then becomes, how low do you need to go?

Should everybody be walking around at 30 milligrams per deciliter?

Is that the solution to eliminating ASCVD?

And the answer is probably not.

It probably depends on your previous exposure, though.

So if I have a patient who's already had two stents placed and has a significant burden of disease, you bet your bottom line they're at 30 milligrams per deciliter of ApoB, even if we have to put three drugs on them to make sure that's the case, because their burden of disease and their lifetime exposure to ApoB has been so high.

But if I have an individual who's 40 years old, who has perfectly pristine coronary arteries and is walking around with an ApoB of 60 milligrams per deciliter, I don't think you need to do a thing.

I think they're just fine.

And again, it's the inability, I think, for people to understand that level of nuance and understanding when it's worth the second squeeze versus when just the sloppy squeeze is good enough.

It's very frustrating for a person like me who craves nuance.

Yeah.

So that's another very important point.

Another point I want to make is you're still dealing with an asymmetric target.

We tell our patients to be closer to two.

Now I know that's just going to get a whole bunch of people on the anti-protein train just losing their mind.

I can just

See the phosphorylation going off right now as they're watching this clip.

How is this guy so irresponsible to tell his patients to eat two grams of protein per kilogram of body weight?