#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
Because obviously at the macro level, they're going to be geroprotective because if you apply them to people with type 2 diabetes and significant obesity and you correct the metabolic dysfunction, you're going to live longer.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
But the real question is, if you take a person who is...
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
of normal weight who does not have type 2 diabetes, but maybe has a higher risk for Alzheimer's disease, and you microdose them.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
So you're giving them 2.5 milligrams per day, which by the way, we are doing in some patients for obscure metabolic condition without obesity.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
So we have patients who have diabetes, but are already at very low body weight.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
We have two patients actually in our practice in this regard.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
After lots of detailed back and forth machination with Ralph DeFranza, who's a previous guest on the podcast, we sort of realized that at least one component of the drug regimen for these patients was going to be a GLP-1 agonist.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
Now, it seemed very counterintuitive to give trizepatide to people who have a BMI of 23, but we've been able to do it without them losing weight.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
So again, very careful strategies around nutrition and the effect on their diabetes is profound.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
These are really interesting cases that maybe at some point, obviously in a de-identified way, it would be interesting to talk about where you have OGTTs that are unrecognizable.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
You simply cannot believe the degree of metabolic dysfunction in a person who otherwise looks the way they look.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
And in one case in particular, it was so confusing that even after all the genetic testing we did, we simply couldn't figure out an answer for this.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
We couldn't understand where the beta cell fatigue was coming from absent a formal diagnosis of type 1 diabetes.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
And within three months of being on 2.5 milligrams of trisepatide, this individual's OGTT had almost normalized.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
And we've managed to do this without any weight loss.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
which is when you look at some of the Alzheimer's biomarkers, which are improving, improving significantly, it begs the question, should this be part of the playbook for an individual who's at high risk?