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Prof Noreen Starling

👤 Speaker
81 total appearances

Appearances Over Time

Podcast Appearances

Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

There are many other questions about what are the other combinations of this sort of drug, duraxone and racib, but indeed other drugs that are also rapidly coming through clinical trials.

509.204 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

For me, this is really the key that unlocks the transformative treatment potential for pancreatic cancer.

521.127 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

So it's going to be a really busy clinical trials landscape.

527.881 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

That is wonderful.

531.875 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

We've been looking for that in pancreatic cancer for such a long time.

532.759 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

I think it's a triumph for science and it's a triumph for patients.

536.532 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

There's two answers to that.

571.53 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

One is the length of time it takes in terms of the regulator to review the data in order to allow the drug to be available.

572.912 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

And within every jurisdiction, there will also need to be reimbursement considerations.

581.866 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

And for the UK, that will be a nice appraisal, which looks at benefit and resource and cost.

586.853 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

That timeline can vary.

593.824 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

You know, I would hope that we can see progress within this next year or certainly within the next couple of years.

595.567 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

But it's such an important breakthrough.

604.441 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

I would hope the system can move quickly in regard to this.

606.163 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

Absolutely.

674.173 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

So the two main other cancers where we can see RAS mutations include non-small cell lung cancer and colorectal cancer.

674.853 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

In fact, RAS mutations might be present in about 50 to 60% of tumours of patients with colorectal cancer.

683.762 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

So there's definitely efforts and trials coming focused on both of these diseases.

692.21 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

There may be additional challenges.

698.887 View full episode →
Science Weekly
‘The undruggable became druggable’: a breakthrough cancer treatment

RAS is not the same in every disease.

700.952 View full episode →