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Professor Luke O'Neill

๐Ÿ‘ค Speaker
827 total appearances

Appearances Over Time

Podcast Appearances

Show Me the Science with Luke O'Neill
The Science of Gut Health

And very nicely, what they've shown is if you're on chemo for multiple types of cancer, it turns out,

Show Me the Science with Luke O'Neill
The Science of Gut Health

If there's a bacteria called Barnacella intestinohomonas, I'll say that again, even I have trouble with these names, Barnacella intestinohomonas, if that species of bacteria, you will have an increased response to chemotherapy.

Show Me the Science with Luke O'Neill
The Science of Gut Health

Now, this could be extremely important because you can imagine where they're going with that.

Show Me the Science with Luke O'Neill
The Science of Gut Health

you will give someone chemo in combination with that bacteria.

Show Me the Science with Luke O'Neill
The Science of Gut Health

And that's what's happening.

Show Me the Science with Luke O'Neill
The Science of Gut Health

They're testing these things as we speak.

Show Me the Science with Luke O'Neill
The Science of Gut Health

Why would a certain bacteria increase their response to chemotherapy?

Show Me the Science with Luke O'Neill
The Science of Gut Health

Well, it turns out the chemotherapy is also affecting the bacteria, activating them, and they get the immune system going.

Show Me the Science with Luke O'Neill
The Science of Gut Health

So in a way, you're mobilizing the immune system through the bacteria to

Show Me the Science with Luke O'Neill
The Science of Gut Health

That's one idea that they're exploring.

Show Me the Science with Luke O'Neill
The Science of Gut Health

And they've got evidence for this.

Show Me the Science with Luke O'Neill
The Science of Gut Health

And for some reason, this barnacella one is especially sensitive to chemo and can release things that provoke the immune system into action to help fight the tumor.

Show Me the Science with Luke O'Neill
The Science of Gut Health

It's a funny discovery that actually the chemo isn't just a poison then.

Show Me the Science with Luke O'Neill
The Science of Gut Health

We know now chemo is also very good at driving the immune response.

Show Me the Science with Luke O'Neill
The Science of Gut Health

either through this route, through bacteria, or through damaging our own cells, which then release things that trigger the immune response as well.

Show Me the Science with Luke O'Neill
The Science of Gut Health

So the combination with chemo is a really interesting area that's developing all the time.