Professor Luke O'Neill

speaker

1,535 appearances 7 recordings 2 series first heard Apr 2026 last heard 3 Sep

Professor Luke O'Neill’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 7 in all, peaking in May 2026 with 3.

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Show Me the Science with Luke O'Neill · The Science of Alzheimer’s · 6 Aug 2026 podcast

The numbers are probably 120 trials running with different approaches now to stop the damage that's being done.

And the drugs that are there at the moment, some will improve thinking a bit and they can be very useful early on.

But the ones that are disease modifying, we call them, they're taking up all the nasty clumps.

So the two drugs, the Camby and the Nanomab, awful mouthfuls, they'll mop up the beta amyloid and get rid of the gunk from that, clean up the brain, if you like.

Now they work a bit.

20% benefit here and there.

There's a side effect.

Some of them cause brain bleeds.

So they aren't the answer.

And some health systems, including in Europe, want to prove them because they're very expensive.

But they're the first step in the right direction that you might be able to slow it down slightly.

And then the most recent one was an antibody to tau.

This other protein, Biogen, had a report on that.

And that mops up the tau, gets rid of the gunk, if you like, and stops the immune system overheating is the idea.

So we'll see if these pan out.

Certainly, they're seen as a start and it should get better.

It's because it's the first time ever they've slowed down disease is the key thing here.

So there will be progress there, we hope.

But meanwhile, if you follow the guidelines, you will see less plaque forming is the overall view.

So these things decrease the risk of plaque.

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