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Professor Matthew Kiernan

๐Ÿ‘ค Speaker
877 total appearances

Appearances Over Time

Podcast Appearances

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

But that's not available at the moment.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

The other thing is when you start knocking out certain genes, you don't know what the downstream effects of that are.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

The knock-on effect is.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

Yeah, exactly.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

Because it might be good for something else.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

Yeah, and it might be a catastrophe.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

There were trials, for instance, in Parkinson's disease, putting in stem cells into the brain and it all sounded great.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

It was looking good.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

But then the stem cells started to overgrow and cause cancer.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

And so people were coming in with overgrowth and cancerous cells in the brain.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

So it was a catastrophe.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

So you've got to be able to understand.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

And that's really why human trials are so critical.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

So a model is only as good as the disease it models.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

But I think we have to get more and more into patients and patients with neurological conditions.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

Of course, we need basic science and discovery, but we've got to focus on the human.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

What is this anxiety about memory?

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

Well, I think once we start focusing on it, we all become anxious.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

Like hearing your story there, I was feeling a bit anxious.

Straight Talk with Mark Bouris
Brain Expert: Why Dementia Is Australia's Number One Killer (Project 100)

So that's something natural.