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Professor Salome Charalambous

๐Ÿ‘ค Speaker
240 total appearances

Appearances Over Time

Podcast Appearances

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

Yeah.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

For sure.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

And, you know, there are so many of these stories and it's always so sad to hear them.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

And, you know, like I am just pleased that we now no longer treat TB for 23 months.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

Hopefully most people only need to take treatment for around six months, even those with drug resistant TB.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

Yeah, so the new regimen that we're using now for drug-resistant tuberculosis is called BPAL.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

It's a great regimen because it's only made up of four drugs.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

In the past, people used to actually be on up to seven drugs.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

And the B stands for bedaquiline.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

So the other drugs are protaminate, linezolid, and then levofloxacin.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

So that makes up BPAL.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

And the good thing about BPAL is that it's an oral โ€“

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

all oral regimen, which means there aren't any injectables involved.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

You know, it's an all oral regimen that is safe and it's now given for six months instead of previously where the regimens were given for nine and 12 and much more.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

So that is the new regimen that people have been using.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

It came in about two, three years ago and it's really revolutionized drug resistant TB treatment.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

So what we do is, so the most common form of TB we call drug sensitive TB.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

And that is in most cases the most common form.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

So, you know, in South Africa where I live, it's 95% of people have drug sensitive TB.

When Science Finds a Way
Is hope on the horizon for treating drug-resistant TB?

And that means that they would then be able to be treated with what we call the first line of treatment, which is the first four drugs that we use.