Richard Scolyer

But you have to prove that by taking a biopsy, and the neuropathology team who are experts in that field will make the final diagnosis.

And these days, as part of the classification, we have to do molecular testing to see what subtype it is.

And when the diagnosis came back, for me, it's...

called an IDH wild-type unmethylated chloroblastoma.

And unfortunately for me, there's a whole heap of other prognostic factors that you can look at, and most of the bad ones I seem to have picked up.

And the standard way it's treated is diagnosis made, debulk as much of the tumour as possible.

So Brenda, the neurosurgeon, would do that.

without causing major functional deficit.

And then three to four weeks after that, start chemotherapy and radiotherapy together.

The radiotherapy goes for six weeks, so daily five days a week.

And the chemotherapy is with a drug called temozolomide, and that goes for six months.

And that treatment was devised and proven in a clinical trial to improve outcomes for patients with glioblastoma.

I think 19 years ago it was published and it's called the Stook Protocol.

So that's the standard treatment for people with glioblastoma.

Yeah, so for me as a man over 50 with the IDH wild type, I'm methylated at 12 months is the average survival.

But we look at survival curves and they're sort of bell-shaped and we talk about the median so you can be on the good or the bad side of that average, if you like.

Well, she suggested, are you interested or going down this path of trying pre-surgery or neoadjuvant immunotherapy, which we're just proving at that stage has a much bigger, more effective way of treating melanoma than...

than giving the treatment after the surgery and never been tried with combination immunotherapy before.

And we know, as we discussed earlier, that the immune system will be suppressed by chemotherapy.

So I've had the temozolomide