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Rick Doblin

👤 Person
1002 total appearances

Appearances Over Time

Podcast Appearances

The Joe Rogan Experience
#2319 - Rick Doblin

And then another roughly 20% had what's called clinically significant reductions of PTSD symptoms, means that their life has changed, their symptoms are not as burdensome, but they still have PTSD. So they're called responders. So we had 88% responders, only 12% non-responders. Wow. It's the best treatment.

The Joe Rogan Experience
#2319 - Rick Doblin

And then another roughly 20% had what's called clinically significant reductions of PTSD symptoms, means that their life has changed, their symptoms are not as burdensome, but they still have PTSD. So they're called responders. So we had 88% responders, only 12% non-responders. Wow. It's the best treatment.

The Joe Rogan Experience
#2319 - Rick Doblin

In the second phase three study, we purposely moved it to moderate to severe PTSD because we didn't want the FDA to say it's only for severe PTSD. Three quarters of the people did have severe PTSD, and one quarter had moderate PTSD. And it was 72.6% no longer had PTSD, almost three quarters no longer had PTSD at this two-month follow-up.

The Joe Rogan Experience
#2319 - Rick Doblin

In the second phase three study, we purposely moved it to moderate to severe PTSD because we didn't want the FDA to say it's only for severe PTSD. Three quarters of the people did have severe PTSD, and one quarter had moderate PTSD. And it was 72.6% no longer had PTSD, almost three quarters no longer had PTSD at this two-month follow-up.

The Joe Rogan Experience
#2319 - Rick Doblin

In the second phase three study, we purposely moved it to moderate to severe PTSD because we didn't want the FDA to say it's only for severe PTSD. Three quarters of the people did have severe PTSD, and one quarter had moderate PTSD. And it was 72.6% no longer had PTSD, almost three quarters no longer had PTSD at this two-month follow-up.

The Joe Rogan Experience
#2319 - Rick Doblin

And what was even more remarkable, and this relates, I think, to the concerns that was expressed about bias and functional unblinding, is that 46% of the people that had therapy with no MDMA also went below the threshold of having a PTSD diagnosis. That's better than any of the other therapies for PTSD.

The Joe Rogan Experience
#2319 - Rick Doblin

And what was even more remarkable, and this relates, I think, to the concerns that was expressed about bias and functional unblinding, is that 46% of the people that had therapy with no MDMA also went below the threshold of having a PTSD diagnosis. That's better than any of the other therapies for PTSD.

The Joe Rogan Experience
#2319 - Rick Doblin

And what was even more remarkable, and this relates, I think, to the concerns that was expressed about bias and functional unblinding, is that 46% of the people that had therapy with no MDMA also went below the threshold of having a PTSD diagnosis. That's better than any of the other therapies for PTSD.

The Joe Rogan Experience
#2319 - Rick Doblin

And so what that demonstrated is that the therapists, even though most of them could tell the difference between whether somebody had MDMA or not, that they tried just as hard as they could to help people, whether they got the MDMA or not. And we got extraordinary results in the control group.

The Joe Rogan Experience
#2319 - Rick Doblin

And so what that demonstrated is that the therapists, even though most of them could tell the difference between whether somebody had MDMA or not, that they tried just as hard as they could to help people, whether they got the MDMA or not. And we got extraordinary results in the control group.

The Joe Rogan Experience
#2319 - Rick Doblin

And so what that demonstrated is that the therapists, even though most of them could tell the difference between whether somebody had MDMA or not, that they tried just as hard as they could to help people, whether they got the MDMA or not. And we got extraordinary results in the control group.

The Joe Rogan Experience
#2319 - Rick Doblin

And I think one of the things that is the explanation is that when you have an eight-hour therapy session with music, with headphones, with more or less half the time people are inside having these different feelings and the other half they're talking to the therapist in no particular order. you're not forced to focus on the therapy the way with prolonged exposure or cognitive processing therapy.

The Joe Rogan Experience
#2319 - Rick Doblin

And I think one of the things that is the explanation is that when you have an eight-hour therapy session with music, with headphones, with more or less half the time people are inside having these different feelings and the other half they're talking to the therapist in no particular order. you're not forced to focus on the therapy the way with prolonged exposure or cognitive processing therapy.

The Joe Rogan Experience
#2319 - Rick Doblin

And I think one of the things that is the explanation is that when you have an eight-hour therapy session with music, with headphones, with more or less half the time people are inside having these different feelings and the other half they're talking to the therapist in no particular order. you're not forced to focus on the therapy the way with prolonged exposure or cognitive processing therapy.

The Joe Rogan Experience
#2319 - Rick Doblin

That's what I said was re-traumatizing in the studies that the VA did. Roughly half the people dropped out. We had very low dropout rates because people are encouraged to just – we support whatever's emerging. That's the essence of the therapeutic approach that has been developed to support people – when they're going through MDMA therapy.

The Joe Rogan Experience
#2319 - Rick Doblin

That's what I said was re-traumatizing in the studies that the VA did. Roughly half the people dropped out. We had very low dropout rates because people are encouraged to just – we support whatever's emerging. That's the essence of the therapeutic approach that has been developed to support people – when they're going through MDMA therapy.

The Joe Rogan Experience
#2319 - Rick Doblin

That's what I said was re-traumatizing in the studies that the VA did. Roughly half the people dropped out. We had very low dropout rates because people are encouraged to just – we support whatever's emerging. That's the essence of the therapeutic approach that has been developed to support people – when they're going through MDMA therapy.

The Joe Rogan Experience
#2319 - Rick Doblin

And it's very similar to what can be done with psilocybin or LSD or even Ibogaine, that you just support whatever's emerging. You have this sense that there's a wisdom of the unconscious. We all know that our body has a certain wisdom in that it moves towards wholeness. We get cuts, it heals. It's below our level of awareness. So there's some kind of wisdom to what's emerging.

The Joe Rogan Experience
#2319 - Rick Doblin

And it's very similar to what can be done with psilocybin or LSD or even Ibogaine, that you just support whatever's emerging. You have this sense that there's a wisdom of the unconscious. We all know that our body has a certain wisdom in that it moves towards wholeness. We get cuts, it heals. It's below our level of awareness. So there's some kind of wisdom to what's emerging.

The Joe Rogan Experience
#2319 - Rick Doblin

And it's very similar to what can be done with psilocybin or LSD or even Ibogaine, that you just support whatever's emerging. You have this sense that there's a wisdom of the unconscious. We all know that our body has a certain wisdom in that it moves towards wholeness. We get cuts, it heals. It's below our level of awareness. So there's some kind of wisdom to what's emerging.