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Rob Wiblin

πŸ‘€ Speaker
3881 total appearances
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Podcast Appearances

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

But yeah, is it the case that we would be fairly likely to know if a country was or a major country was having a large bioweapons program or if they had a significant, they had gone out of their way to release a bioweapon deliberately for strategic purposes?

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

So that's the main thing that we can do to discourage major countries from pursuing or releasing biological weapons is just to create, I guess, the potential for very severe consequences after the fact.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Do you have a proposal?

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

This is as good a time as any to ask.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Do you have a top way of reducing the risk that AI enables mirror bacteria to be created sooner or released?

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Yeah, I think that's a good one.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

So as I said earlier, you think that an important project is trying to develop broad spectrum vaccines and broad spectrum antivirals that we could stockpile or deploy ahead of time that would give us protection against new bioweapons that might create it from that virus class.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Tell us more about why that stands out to you.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

So we won't be brought to our knees, basically.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Precisely.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

So presumably people have been interested in broad-spectrum antivirals and broad-spectrum vaccines for a long time.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

It's a great idea for obvious reasons.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

But why do you think it might be actually technically feasible in the near future in a way that it hasn't been so far?

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Okay, so the basic idea with the broad spectrum or universal vaccine would be that you give people a ton of different antigens, or you expose people to lots and lots of different flu-like shapes in the injection, and that will prompt an immune response against many different, slightly different, what do you call it, like antigen, the proteins that are outward facing on the virus.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

So that's one way of doing it, yes.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

And I guess another one might be to do mRNA, and you put in lots of somewhat different sequences.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

But if there's like one part of it that doesn't change, why weren't we targeting that already?

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Okay.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

And I guess with the antivirus, I mean, we have like shockingly few antivirals, I guess, to start with compared to antibiotics.

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

We do.