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Sid Sijbrandij

๐Ÿ‘ค Speaker
634 total appearances

Appearances Over Time

Podcast Appearances

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

Maybe not going to be friends.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

Yeah, we assume that it's not gone.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

And the only reason it'd be gone, we know that the surgery didn't cure it, that they left so-called positive margins.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

The only thing that was remarkable when we...

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

the cancer we've removed, we were able to flesh free some of it, which is amazing for people with cancer.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

It's way better to flesh free stuff because it allows you to do many, many more

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

diagnosis on it later than if you do the standard, which is FFPE, which preserves it, but it precludes you from doing a ton of tests.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

So if you want to have an active role in your treatment, you've got to convince the hospital to flesh-free some of it so that you preserve optionality to run these diagnostics later.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

And what we saw was that the T-cell infiltration went up a lot.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

It went up from 20% to 90%.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

So the place was buzzing with T cells, which is a good thing.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

And we think that is a combination of the two checkpoint inhibitors that I'm taking that kind of unleash your immune system and one experimental treatment that is an oncolytic virus, so like a modified common cold virus

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

that drops the TGF beta.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

And the TGF beta is something the cancer uses to hide from the immune system.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

And it kind of tears away that invisibility cloak.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

We don't super think that that's curative.

The Changelog: Software Development, Open Source
From GitLab to Kilo Code (Interview)

But I'm gearing up in two weeks to take an mRNA vaccine.