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Sir John Bell

👤 Person
240 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

clinical data on any of these people.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

So I said, yeah, yeah, okay, I get it.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

Just give us the money and let us get on.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

So anyway, it's quite an interesting story because it does show how conservative the community actually is for new ideas.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

We then...

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

I chaired the first science committee and we decided about a year into it that we really needed a chief executive.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

So we got Rory Collins to lead it and he's done it.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

I sat on the board then for the next 10 years, but it will look, it was a great success.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

And as you say, it is kind of the paradigm for now large companies.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

global cohorts, genetic epidemiology cohorts.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

So then, as you know, I advised government for many years and David Cameron had just been elected as prime minister.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

This was in about 2010.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

And at the time,

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

I'd been tracking, because we had quite a strong genomics program in the Wellcome Trust Center, which I'd set up in the university, and we were really interested in the genetics of common disease.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

And it became clear that the price of sequencing, and Illumina was now the clear leader in the sequencing space, but it was also clear that Illumina was making significant advances in the price of sequencing, because as you remember the days when it cost $5,000 to do a genome.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

Anyway, it became clear that they actually had technology that gets you down to a much more sensible price, something like $500 a genome.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

So I approached David and I said, you know, we're now pretty sure that for many of the rare diseases that you see in clinical practice,

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

There is a genetic answer that can be detected if you sequenced a whole genome.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

So why don't we set something up in the NHS to provide what was essentially the beginnings of a clinical service to help the parents of kids with various disabilities work out what's going on, what's wrong with their children.

Ground Truths
Sir John Bell: Transforming Life Science and Medicine's Future

And David had had a child with Odahara syndrome, which as you know is again... And so David was very... He said, oh God, I'll tell you the story about how awful it was for...