Theresa MacPhail
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Podcast Appearances
But it's producing symptoms that would seem familiar to someone whose immune cells, whose T cells and B cells are producing antibodies and attacking that milk protein. Except that the allergy can, you know, escalate. You can get a skin rash, you can get wheezing, and you can end up in the ER with a full-on anaphylactic event. That's not going to happen with intolerance.
But it's producing symptoms that would seem familiar to someone whose immune cells, whose T cells and B cells are producing antibodies and attacking that milk protein. Except that the allergy can, you know, escalate. You can get a skin rash, you can get wheezing, and you can end up in the ER with a full-on anaphylactic event. That's not going to happen with intolerance.
But it's producing symptoms that would seem familiar to someone whose immune cells, whose T cells and B cells are producing antibodies and attacking that milk protein. Except that the allergy can, you know, escalate. You can get a skin rash, you can get wheezing, and you can end up in the ER with a full-on anaphylactic event. That's not going to happen with intolerance.
But if you have mild forms of this, you're going to be confused and you might just assume that you have an allergy. And the only way to know for certain is to see an allergist. The problem there is we don't really have enough of them. They're specialists and you need a referral to see one. And so a lot of people are out there self-diagnosing.
But if you have mild forms of this, you're going to be confused and you might just assume that you have an allergy. And the only way to know for certain is to see an allergist. The problem there is we don't really have enough of them. They're specialists and you need a referral to see one. And so a lot of people are out there self-diagnosing.
But if you have mild forms of this, you're going to be confused and you might just assume that you have an allergy. And the only way to know for certain is to see an allergist. The problem there is we don't really have enough of them. They're specialists and you need a referral to see one. And so a lot of people are out there self-diagnosing.
We think as far as we can tell that they are rising, but it's complicated. We know that rates of asthma and hay fever started to rise post-World War II, like 1950s, 1960s, and continued right up until the 1990s. And now they seem to have been flattened. But what has been rising in the wake of that are rates of food allergies. We know this because of several reasons.
We think as far as we can tell that they are rising, but it's complicated. We know that rates of asthma and hay fever started to rise post-World War II, like 1950s, 1960s, and continued right up until the 1990s. And now they seem to have been flattened. But what has been rising in the wake of that are rates of food allergies. We know this because of several reasons.
We think as far as we can tell that they are rising, but it's complicated. We know that rates of asthma and hay fever started to rise post-World War II, like 1950s, 1960s, and continued right up until the 1990s. And now they seem to have been flattened. But what has been rising in the wake of that are rates of food allergies. We know this because of several reasons.
One is you can look at ER visits. You can see when someone is showing up with asthma or with a rash, like a very bad eczema eruption, or they are having anaphylaxis. The other thing that we can track is EpiPen or adrenaline prescriptions. Those raised three to four times from the 1990s to around 2018, 2019.
One is you can look at ER visits. You can see when someone is showing up with asthma or with a rash, like a very bad eczema eruption, or they are having anaphylaxis. The other thing that we can track is EpiPen or adrenaline prescriptions. Those raised three to four times from the 1990s to around 2018, 2019.
One is you can look at ER visits. You can see when someone is showing up with asthma or with a rash, like a very bad eczema eruption, or they are having anaphylaxis. The other thing that we can track is EpiPen or adrenaline prescriptions. Those raised three to four times from the 1990s to around 2018, 2019.
Right. So in the 1980s, this is after the massive rise of asthma, we're starting to see food allergies. An epidemiologist was curious about this and started collecting data on families and realized that older siblings seem to have more allergic disease than younger siblings. The theory was that older siblings bring home colds and track in bugs to expose their younger siblings.
Right. So in the 1980s, this is after the massive rise of asthma, we're starting to see food allergies. An epidemiologist was curious about this and started collecting data on families and realized that older siblings seem to have more allergic disease than younger siblings. The theory was that older siblings bring home colds and track in bugs to expose their younger siblings.
Right. So in the 1980s, this is after the massive rise of asthma, we're starting to see food allergies. An epidemiologist was curious about this and started collecting data on families and realized that older siblings seem to have more allergic disease than younger siblings. The theory was that older siblings bring home colds and track in bugs to expose their younger siblings.
And there was something about that earlier exposure that had somehow protected these younger siblings. It was called the hygiene hypothesis. That has morphed over the years to what is now called the old friends hypothesis. which is nice, isn't it? That's a nicer way to put it.
And there was something about that earlier exposure that had somehow protected these younger siblings. It was called the hygiene hypothesis. That has morphed over the years to what is now called the old friends hypothesis. which is nice, isn't it? That's a nicer way to put it.
And there was something about that earlier exposure that had somehow protected these younger siblings. It was called the hygiene hypothesis. That has morphed over the years to what is now called the old friends hypothesis. which is nice, isn't it? That's a nicer way to put it.
That there's something about getting the right exposures to the right bacteria or the right viruses and fungi that will help train our immune system. You're born with a novice, a naive immune system that hasn't seen anything.
That there's something about getting the right exposures to the right bacteria or the right viruses and fungi that will help train our immune system. You're born with a novice, a naive immune system that hasn't seen anything.