Tina Moore

drop of your resting metabolic rate that is larger than expected it's bigger than anticipated this is what happens when people have a big drop in weight that's metabolic adaptation aka adaptive thermogenesis it's your body going we're starving slow down everything and conserve energy so everything's going to slow down your thyroid function everything's going to slow down your metabolic rate everything's going to slow down because the body's slamming the brakes saying we are starving

drop of your resting metabolic rate that is larger than expected it's bigger than anticipated this is what happens when people have a big drop in weight that's metabolic adaptation aka adaptive thermogenesis it's your body going we're starving slow down everything and conserve energy so everything's going to slow down your thyroid function everything's going to slow down your metabolic rate everything's going to slow down because the body's slamming the brakes saying we are starving

drop of your resting metabolic rate that is larger than expected it's bigger than anticipated this is what happens when people have a big drop in weight that's metabolic adaptation aka adaptive thermogenesis it's your body going we're starving slow down everything and conserve energy so everything's going to slow down your thyroid function everything's going to slow down your metabolic rate everything's going to slow down because the body's slamming the brakes saying we are starving

Do not lose any more weight. This is why I'm not a fan of losing weight quickly. This is why I tell you we don't wanna lose more than one pound a week because we don't want to go into a hyper response of metabolic adaptation. We expect a little bit, right? Because a leaner body needs less calories to run, but we don't wanna slam the brakes here. So think of your body as a furnace.

Do not lose any more weight. This is why I'm not a fan of losing weight quickly. This is why I tell you we don't wanna lose more than one pound a week because we don't want to go into a hyper response of metabolic adaptation. We expect a little bit, right? Because a leaner body needs less calories to run, but we don't wanna slam the brakes here. So think of your body as a furnace.

Do not lose any more weight. This is why I'm not a fan of losing weight quickly. This is why I tell you we don't wanna lose more than one pound a week because we don't want to go into a hyper response of metabolic adaptation. We expect a little bit, right? Because a leaner body needs less calories to run, but we don't wanna slam the brakes here. So think of your body as a furnace.

Here's a scenario. You lose 30 pounds, all right? What should happen? Your furnace turns down to low. What actually happens is your furnace goes into hibernation mode because of this metabolic adaptation. Or say you lose 10 pounds, your furnace should drop by 150 calories a day. Instead, it drops to 300 calories a day, which is extra slowdown. That's metabolic adaptation, all right?

Here's a scenario. You lose 30 pounds, all right? What should happen? Your furnace turns down to low. What actually happens is your furnace goes into hibernation mode because of this metabolic adaptation. Or say you lose 10 pounds, your furnace should drop by 150 calories a day. Instead, it drops to 300 calories a day, which is extra slowdown. That's metabolic adaptation, all right?

Here's a scenario. You lose 30 pounds, all right? What should happen? Your furnace turns down to low. What actually happens is your furnace goes into hibernation mode because of this metabolic adaptation. Or say you lose 10 pounds, your furnace should drop by 150 calories a day. Instead, it drops to 300 calories a day, which is extra slowdown. That's metabolic adaptation, all right?

So now let's apply it to these studies. In caloric restriction, let's say you lose 10 to 15% of your body weight. You should see about 150 calorie a day resting metabolic rate drop. but what you actually see is a 250 to 300 calorie a day drop, meaning it overcompensated. That's metabolic adaptation. This is this extra unwanted slowdown, okay?

So now let's apply it to these studies. In caloric restriction, let's say you lose 10 to 15% of your body weight. You should see about 150 calorie a day resting metabolic rate drop. but what you actually see is a 250 to 300 calorie a day drop, meaning it overcompensated. That's metabolic adaptation. This is this extra unwanted slowdown, okay?

So now let's apply it to these studies. In caloric restriction, let's say you lose 10 to 15% of your body weight. You should see about 150 calorie a day resting metabolic rate drop. but what you actually see is a 250 to 300 calorie a day drop, meaning it overcompensated. That's metabolic adaptation. This is this extra unwanted slowdown, okay?

In this study, interestingly, let's talk about the mice first. So the mice lost an appreciable amount of weight. They had their metabolic adaptation attenuated by the triseptide, meaning halted. or lowered even. So they did not get the expected nor the hyper response of metabolic adaptation that one would expect when you lose an appreciable amount of weight. They had no metabolic slowdown.

In this study, interestingly, let's talk about the mice first. So the mice lost an appreciable amount of weight. They had their metabolic adaptation attenuated by the triseptide, meaning halted. or lowered even. So they did not get the expected nor the hyper response of metabolic adaptation that one would expect when you lose an appreciable amount of weight. They had no metabolic slowdown.

In this study, interestingly, let's talk about the mice first. So the mice lost an appreciable amount of weight. They had their metabolic adaptation attenuated by the triseptide, meaning halted. or lowered even. So they did not get the expected nor the hyper response of metabolic adaptation that one would expect when you lose an appreciable amount of weight. They had no metabolic slowdown.

So everybody thought, okay, mice studies, terzapatide must be really protective to metabolic health and there's no appreciable metabolic adaptation, so yahoo. And they erroneously apply this to humans, which we do. This is why I always try to clarify these are rodent studies or not, because it doesn't always translate to humans.

So everybody thought, okay, mice studies, terzapatide must be really protective to metabolic health and there's no appreciable metabolic adaptation, so yahoo. And they erroneously apply this to humans, which we do. This is why I always try to clarify these are rodent studies or not, because it doesn't always translate to humans.

So everybody thought, okay, mice studies, terzapatide must be really protective to metabolic health and there's no appreciable metabolic adaptation, so yahoo. And they erroneously apply this to humans, which we do. This is why I always try to clarify these are rodent studies or not, because it doesn't always translate to humans.

But what they found in this study in the humans, when they looked at the 55 individuals that were split pretty evenly down the middle into two groups, they were on 15 milligrams of Tuer's appetite a week. That's a hefty dose. That's like the highest end of the entire dosing protocol. So they were on the highest dose. They were titrated up over like, I think, 20 weeks.

But what they found in this study in the humans, when they looked at the 55 individuals that were split pretty evenly down the middle into two groups, they were on 15 milligrams of Tuer's appetite a week. That's a hefty dose. That's like the highest end of the entire dosing protocol. So they were on the highest dose. They were titrated up over like, I think, 20 weeks.