The Dr. Tyna Show
Tirzepatide + Metabolic Health: What the Latest Study Really Shows | Solo
Fri, 18 Apr 2025
EP. 207: A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I’ve got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn’t tell the whole truth. There’s more going on here, and you deserve the full picture. Topics Covered: Does tirzepatide help with metabolic health beyond calorie restriction leading to weight loss? How does it affect metabolic adaptation in people with obesity? Can it boost fat oxidation? Is the “calories in, calories out” model outdated for GLP-1s? What does this mean for long-term metabolic health? Sponsored By: Qualia | Go to qualialife.com/DRTYNA for up to 50% off your purchase and use code DRTYNA for an additional 15% Sundays | As a Listener of The Dr Tyna Show, you can Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. Liver Love | Go to https://store.drtyna.com/products/liverlove Use code DRTYNASHOW at checkout to save. LMNT | Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna BIOptimizers | For an exclusive offer on MassZymes go to Bioptimizers.com/DRTYNA and use promo code DRTYNA On This Episode We Cover: 00:00:00 – Introduction 00:02:44 – Obesity study on GLP1s and weight loss 00:04:21 – Calories in vs. calories out 00:05:44 – Resting metabolic rate 00:09:25 – Metabolic adaptation during dieting 00:12:11 – Tirzepatide dosing in clinical studies 00:15:49 – Maintaining weight loss 00:18:15 – GLP1s & increased fat oxidation 00:19:14 – GLP1 microdosing myths 00:26:06 – Metabolic rate drops vs. metabolic improvements 00:29:51 – Lessons from the Biggest Loser study 00:34:20 – Study Comparation 00:35:25 – Weight loss, inflammation, and aging 00:36:35 – Health autonomy 00:40:23 – Caloric restriction and the CALERIE study Studies Mentioned: Tirzepatide Did Not Impact Metabolic Adaptation In People With Obesity, But Increased Fat Oxidation Persistent Metabolic Adaptation 6 Years After The Biggest Loser Competition Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Show Links GLP-1s Done Right University Dr. Tyna’s Strength Corner Metabolic Revamp Toolkit + Masterclass Further Listening: GLP1s Uncovered (Free Class) EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knapp Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
Chapter 1: What is tirzepatide and how does it work?
For those of you who haven't seen The Biggest Loser, it was terrible. They basically put these people in a camp for 30 weeks and just pummeled them. What happened? Their resting metabolic rate dropped by 500 calories a day on average. This was a 275 calorie a day lower than predicted. This was severe, severe metabolic adaptation as an example.
Six years later, most had regained the weight and their resting metabolic rates were still suppressed, which leads me to believe, I don't know if they followed them past that, but it leads me to believe that
this might be forever and i've heard this in the obesity community and i've been studying obesity pretty intensely for the past two years and i have a whole newfound appreciation for obesity as a disease go back and listen to the episode i just did with dave knapp he's the on the pen guy that's his platform on the pen really really nice guy independent journalist he lives with the disease of obesity and he talks about it quite a bit and i think he represents it well
But the bottom line was these folks on The Biggest Loser, their bodies were stuck in starvation mode, maybe forever, permanently is what it looked like. That's what's happening to people who are losing massive calories or restricting massive calories in a short amount of time and losing massive amounts of weight.
But the thing is, is this small study showed that terzapatide is protective against that. I would say that's a massive win. It's significantly better than just saying, oh, they lost weight because they ate less. There was the CALERIE study, C-A-L-E-R-I-E study, long-term caloric restriction in non-obese humans. The summary was that participants restricted calories for 25%,
for two years they lost moderate weight 10 to 15 of their body weight the metabolic effects they also experience metabolic adaptation their resting metabolic rate declined more than expected they increased fatigue cold sensitivity hormonal suppression your thyroid just gets tanked out in this case sex hormones your estrogen your testosterone progesterone and elevated hunger so what these studies show us is that typical dieting causes the body to fight back it pushes back
The bigger the calorie gap, the harder your metabolism hits the brakes and weight loss is achieved at the cost of long-term metabolic health. So all these folks out there, all these folks online saying it's just calories in, calories out, eat less calories, track your calories, track your macros, track your calories. I will say track your macros.
I mean, don't worry about any of them except eat enough protein is my stance on it. If you get enough protein in, you're not going to have any room to be shoving in a bunch of terrible macros on top of it.
But any of these folks helping everyone in the world with their caloric restriction, I really encourage them to track their clients and let me know how they're doing a year later or two years later or three years later. Because I've helped many patients with caloric restriction and metabolic adaptation is real yo. And it is brutal. And it's very hard for those folks to maintain that weight loss.
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Chapter 2: What does the latest study say about tirzepatide?
And then from there for the general public, I'm going to have a much more dialed in, way less clinical. Although some people really want that information. That's why I'm saying if you want that information, buy the course now because it's going away. But there will be a much more just action-packed how to like support your journey with GLP-1 type of program. That's coming last.
So if you are in any of those tiers of people that encompasses everyone, actually, you're either a prescribing doctor, you are a health professional that's non-licensed, or you don't have a prescribing license, or you're the general population, general public, I encourage you if you want the beefy version as it stands, the comprehensive OG version that I built out
gosh, a year ago, a little over a year ago, grab the course as it stands. So go to drtina.com forward slash Ozempic Uncovered. Watch the four-part video series. You'll get a new video each day. I believe the third day in, you'll get the invitation to purchase the course. I highly encourage you to do it. That's the best price you're going to get.
And it's going to go away soon, so it's not even going to be available. All right. Much love, guys. Thank you. I hope this was helpful. Again, I will make sure to link this study for you, but you are only going to be able to read, I think, the first page of it before it cuts you off and makes you pay for it. So I've covered it here. You can buy it if you want and read it.
But I think at the end of the day, what it's showing us is terzapatide is very protective for your metabolism and your metabolic health and potentially If we're having fat oxidation increase, it's doing something well beyond just helping you reduce your calories more. I will bid you adieu. And if you like this episode, please rate, review and subscribe on your favorite podcast app.
You can also find all of my offerings on my website at drtina.com. For more shows by my team, go to wellnessloud.com. See you next time and thanks for listening. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk.
The content on this podcast is intended not to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice from any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.
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