Venki Ramakrishnan

So they have to figure out which factors are actually relevant to aging. And then they have to find out how they work. And then they have to figure out if they could actually use it in some therapeutic way. But the amazing thing is as soon as this... these findings were published by Randall and others at Stanford, they started getting all sorts of weird phone calls from creepy people.

So they have to figure out which factors are actually relevant to aging. And then they have to find out how they work. And then they have to figure out if they could actually use it in some therapeutic way. But the amazing thing is as soon as this... these findings were published by Randall and others at Stanford, they started getting all sorts of weird phone calls from creepy people.

And there were all these companies that sprang up which would collect information blood donation, well, they would buy blood from young donors and then sell them at presumably at a huge markup to, you know, rich old people who wanted a transfusion. And there's no evidence that any of this actually worked in humans, you know, and certainly not over the long term. So that's how it is.

And there were all these companies that sprang up which would collect information blood donation, well, they would buy blood from young donors and then sell them at presumably at a huge markup to, you know, rich old people who wanted a transfusion. And there's no evidence that any of this actually worked in humans, you know, and certainly not over the long term. So that's how it is.

And that's a... I have to say that's characteristic of the aging field. Scientists will make a completely bona fide discovery. in animals, the original scientists often, but not always, okay? I should say there are a number of scientists who are also, you know, have a kind of agenda. But by and large, scientists will be somewhat cautious and want to proceed rigorously.

And that's a... I have to say that's characteristic of the aging field. Scientists will make a completely bona fide discovery. in animals, the original scientists often, but not always, okay? I should say there are a number of scientists who are also, you know, have a kind of agenda. But by and large, scientists will be somewhat cautious and want to proceed rigorously.

But then outside parties will jump on it and then try to commercialize it or hype it up. or use some sort of supplement that they think will activate this phenomenon. So there's a huge amount of hype in the field. And I've tried to kind of try to separate the rigorous science and the biology from the hype.

But then outside parties will jump on it and then try to commercialize it or hype it up. or use some sort of supplement that they think will activate this phenomenon. So there's a huge amount of hype in the field. And I've tried to kind of try to separate the rigorous science and the biology from the hype.

Because even knowing the rigorous biology, there are lots of things we can do that will help us age more healthily. So it's not as if You know, there's nothing we can do, and we have to wait around for this industry to come up with something. There are things we can do now, and then potentially there may be more powerful things later.

Because even knowing the rigorous biology, there are lots of things we can do that will help us age more healthily. So it's not as if You know, there's nothing we can do, and we have to wait around for this industry to come up with something. There are things we can do now, and then potentially there may be more powerful things later.

Yes, that's very perceptive. So that was a question people asked that maybe the young mouse was actually acting like a dialysis machine, for example, cleaning out the old blood because its organs and kidneys were better and so on. But what people did was then they took actual young blood from the young mouse without connection. and gave it to an old mouse and did vice versa.

Yes, that's very perceptive. So that was a question people asked that maybe the young mouse was actually acting like a dialysis machine, for example, cleaning out the old blood because its organs and kidneys were better and so on. But what people did was then they took actual young blood from the young mouse without connection. and gave it to an old mouse and did vice versa.

And there, it's interesting, they found that the old blood actually was more deleterious to the young mouse than the young blood was beneficial to the old mouse. And that perhaps why these transfusions

And there, it's interesting, they found that the old blood actually was more deleterious to the young mouse than the young blood was beneficial to the old mouse. And that perhaps why these transfusions

aren't quite having as big an effect as you as as you might have hoped you know brian johnson the tech billionaire who spends i i guess i'm told he spends like two million dollars a year on various longevity treatments and diagnostics And clearly, he has an agenda. He says he thinks of himself as an experimental animal out at the forefront.

aren't quite having as big an effect as you as as you might have hoped you know brian johnson the tech billionaire who spends i i guess i'm told he spends like two million dollars a year on various longevity treatments and diagnostics And clearly, he has an agenda. He says he thinks of himself as an experimental animal out at the forefront.

And he wants to try all the stuff and be an aging pioneer, if you like. Anyway, he did this intergenerational transfer where he took blood from his son, gave it to himself, and then he gave blood to his father. So it's a sort of three-generation. I joke he was keeping it all in the family. Anyway, but after a while, he was also measuring all these various markers of aging.

And he wants to try all the stuff and be an aging pioneer, if you like. Anyway, he did this intergenerational transfer where he took blood from his son, gave it to himself, and then he gave blood to his father. So it's a sort of three-generation. I joke he was keeping it all in the family. Anyway, but after a while, he was also measuring all these various markers of aging.

And I think he came to the conclusion it wasn't having much of an effect, and I think he stopped.

And I think he came to the conclusion it wasn't having much of an effect, and I think he stopped.