Description
真核生物细胞的每条染色体末端都包含着一种被称为端粒的结构，而癌细胞通常具有更长的端粒，尤其是黑色素瘤细胞更是具有惊人的长端粒。匹茨堡大学和加州大学圣克鲁兹分校的研究人员发现，TPP1基因启动子突变，与TERT基因启动子突变共同发生，协同作用，激活TERT表达和活性，从而增强黑色素瘤细胞中的端粒长度维持和永生。
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