In the 3rd episode of this series, Dr Vinchi and I will talk about different facets of heme biology, why heme is crucial in normal physiology and why it exerts a deleterious action when it is not tightly bound to a protein. We will further examine the modulatory role of heme in diseases characterized by excessive free heme in circulation and how endothelial cells in vessels and specific immune cells, called macrophages, adapt their function in response to heme. We hope you will enjoy our conversation with Dr Vinchi and learn more about the heme molecule and its effects in human pathologies.
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