The Science of Longevity: Neal Mercado on Ageing Better, Not Just Longer

I’m joined by Neal Mercado, Chief Science Officer at Melrose, one of Australia’s leading wellness brands and the team behind Melrose Future Lab. Neal leads a thought-provoking conversation on ageing, vitality, and the science behind what really works. We unpack the difference between lifespan and health span—because it’s not just about living longer, but living well. From cellular senescence to musculoskeletal strength, we look at ingredients leading wellness conversations and the future of longevity science.  Neal also lifts the lid on supplement quality, why not all extracts are created equal, and explains the concept of bioavailability to actually move the needle. If you’re navigating perimenopause, curious about longevity, embarking on strength training, or trying to make sense of the supplement aisle, this episode will help you cut through the noise and make informed, future-focused choices. In partnership with Melrose Future Lab. Key Takeaways: Health span means more years lived well, not just longer Cellular senescence (aka “zombie cells”) reduces function as we age Berberine can support healthy blood glucose and AMPK activation Quality matters: not all herbal extracts or proteins are created equal Collagen, especially bovine-derived, supports muscle health Strength training is essential for bone density in menopausal women Supplement bioavailability is as important as the ingredients themselves Innovative formulations are changing how we absorb nutrients Menopause research is decades behind other women’s health areas Perimenopausal women benefit from tailored support and active nutrients Intermittent fasting and autophagy support cellular repair Effective supplements are about formulation—not fads Chapter: 00:00 – The Importance of Health Span vs Longevity03:05 – Understanding the Hallmarks of Ageing05:58 – Cellular Mechanisms of Ageing and Longevity09:12 – The Role of Supplements in Ageing Well11:59 – Berberine: A Key Player in Longevity15:02 – Navigating the World of Supplements18:02 – The Future of Health and Wellness26:32 – Musculoskeletal Health and Ageing34:00 – Innovations in Formulation and Bioavailability38:01 – Addressing Menopause and Perimenopause45:23 – The Importance of Formulation Over Ingredients Watch the full episode here: https://youtu.be/i65uno_HZQoSee omnystudio.com/listener for privacy information.

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