Agentic
Live Vibe Coaching with the LLM Pioneer Who Scaled Before ChatGPT | Will Manidis
12 Jun 2025
Is your AI startup built to survive the next wave?In this episode of Agentic, Will Manidis, the co-founder of ScienceIO, shares how he built for resilience from day one developing LLMs for healthcare and the frameworks that helped him scale before the world caught up.He shares how local model training on office gaming PCs laid the unlikely foundation for ScienceIO’s reach across millions in digital health.We also discuss:• why OpenAI’s API continues to dominate Gemini• the hidden fragility behind $500M fast scaling AI companies• Will’s belief that founders must prove value before overbuilding for scaleNot often do you get to learn from someone who built an LLM before ChatGPT. Tune in now.If you’re in the early innings of building something in AI, especially if you’re figuring things out from first principles—click here, we'd love to hear from you.Connect with us here:1. Will Manidis- https://www.linkedin.com/in/willmanidis/ 2. George Bandarian- https://www.linkedin.com/in/georgebandarian/ 3. Untapped Ventures- https://www.linkedin.com/company/untappedventures/00:00 Trailer01:41 Introduction02:45 Thiel Fellow07:40 Pre-ChatGPT LLMs10:27 Biggest lessons12:37 Contrarian takes13:56 Difficult to sell15:59 First exit16:38 Getting world-class talents23:20 Risk mitigation strategy25:48 Defensibility and moats37:10 Basic MVP44:01 Q&A50:35 Outro
No persons identified in this episode.
This episode hasn't been transcribed yet
Help us prioritize this episode for transcription by upvoting it.
Popular episodes get transcribed faster
Other recent transcribed episodes
Transcribed and ready to explore now
NPR News: 12-08-2025 2AM EST
08 Dec 2025
NPR News Now
NPR News: 12-07-2025 11PM EST
08 Dec 2025
NPR News Now
NPR News: 12-07-2025 10PM EST
08 Dec 2025
NPR News Now
Meidas Health: AAP President Strongly Pushes Back on Hepatitis B Vaccine Changes
08 Dec 2025
The MeidasTouch Podcast
Democrat Bobby Cole Discusses Race for Texas Governor
07 Dec 2025
The MeidasTouch Podcast
Fox News Crashes Out on Air Over Trump’s Rapid Fall
07 Dec 2025
The MeidasTouch Podcast