E185: Use of xAI in Small Cohort Clinical Trials to Identify Biomarkers of Best Responders

In this episode, we explore how Explainable AI (XAI) is revolutionizing drug development, rare disease research, and precision medicine.Our guest, Frédéric Parmentier, Vice President of Data Science at Ariana Pharma, shares how their Explainable Artificial Intelligence (XAI) platform, KEM (Knowledge Extraction and Management), helps uncover critical biomarker signatures in small cohort clinical trials. Unlike traditional black box AI models, XAI delivers transparent, interpretable results that regulators and clinicians can trust—making it a game-changer for early-phase drug development, rare disease trials, and personalized medicine.We dive into:Why Explainable AI in clinical trials is essential for regulatory acceptance and scientific validation.How XAI can identify biomarkers of best responders in cohorts as small as 20–100 patients.Real-world examples where AI revealed insights that traditional statistics missed.The future of AI in drug development, precision medicine, and rare disease research.The difference between black box AI vs. Explainable AI in healthcare and why transparency matters.If you work in biopharma, clinical research, AI-driven healthcare, or drug discovery, this episode will give you powerful insights into how XAI can accelerate development, reduce trial failures, and enable personalized treatment strategies.About the PodcastAI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget. As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses. This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more. Dr. Andree Bates LinkedIn | Facebook | Twitter

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