E194: The Digital Twin Revolution: Reimagining Clinical Trials

In this episode, we explore one of the most disruptive advancements currently reshaping the pharmaceutical and biotech industry: AI-powered digital twins for clinical trials.Our guest, Aaron Smith, PhD — Founder and Head of Machine Learning at Unlearn.AI — breaks down how digital twins and generative AI are transforming drug development by enabling faster, smaller, and more efficient clinical trials.Unlearn.AI builds digital twin models: virtual patient replicas created using clinical trial data, registry data, and real-world data. These digital twins allow researchers to simulate how a patient’s disease will progress under standard care, long before a clinical trial is completed. When combined with randomized controlled trials, this technology reduces data variability, increases trial power, and can dramatically shrink sample sizes and timelines.Some pharma companies are already estimating a six-month reduction in time-to-market, with millions saved in development and operational costs.What You’ll LearnWhat digital twins are and how they simulate patient outcomes using real-world clinical data.How AI is enabling smaller Phase III trials without sacrificing statistical power.Why digital twins are helping pharma identify which patients are most likely to benefit from specific treatments.The biggest barriers to adopting AI in drug development (hint: it’s not the regulators — it’s culture).Trends shaping the future of clinical trials and precision medicine over the next 10 years.Digital twins reduce variability and increase power by predicting how each patient would progress under standard care.The approach (called Prognostic Covariate Adjustment / ProCova) can be used in traditional randomized controlled trials.Pharma partners expect significant reductions in trial timelines and costs.AI enables precision trial design by identifying the most prognostic patient features and outcome measures.About the PodcastAI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget. As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses. This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so...

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