AI Inside
Inside Microsoft Agent 365: How AI Workers Will Be Secured, Identified, and Governed
18 Nov 2025
Microsoft is introducing Agent 365, a new control plane for managing AI agents across the enterprise. Charles Lamanna, the executive leading Microsoft’s Business Apps and Agents division, joins us to explain the ideas behind the launch and why the company believes AI workers will soon be as common as apps or devices. We explore how agents already operate inside organizations, how identity and permissions will work for autonomous systems, and how Microsoft plans to detect and govern rogue agents. If you want to understand the strategy and engineering thinking behind one of Microsoft’s biggest AI bets, this is the episode to hear. Note: Time codes subject to change depending on dynamic ad insertion by the distributor. CHAPTERS: 00:00 – Podcast begins 01:51 – Introducing Charles Lamanna 02:45 – Why Microsoft Is Launching Agent 365 at Ignite 04:37 – How AI Agents Are Already Appearing Inside Companies 06:24 – Customer Fears About Agent Autonomy and Trust 08:40 – How Builders Know When They’ve Created a True “Agent” 11:33 – How Microsoft Detects Agents That Aren’t Registered 13:43 – How Agent 365 Will Audit and Govern AI Agents 17:05 – Real-World Examples of Agents Delivering Results 19:08 – Automatic Agent Registration and Future Telemetry Signals 20:07 – Using Agent 365 in Non-Microsoft Environments 20:38 – Whether Agent 365 Becomes the Directory for All Agents 22:25 – How Agent 365 Handles Bad or Misbehaving Agents 24:10 – What a “Bad Agent” Actually Means in Practice 25:55 – What Success Looks Like After Six to Twelve Months 30:16 – First Steps for Organizations Beginning Their Agent Journey 31:00 – Closing and thanks to Charles Lamanna Learn more about your ad choices. Visit megaphone.fm/adchoices
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