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Alert Medic 1

Journal Club: Analysis of the ZODIAC Trial

04 Oct 2025

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Summary generated by RIVERSIDE AI: In this conversation, Mustafa Sidik and Josh Cooke sit down with Kenny Barajas discuss the implications of the ZODIAC trial (linked below), which investigates the effects of head positioning on stroke patients awaiting thrombectomy. They explore the trial's findings, limitations, and the importance of research literacy in emergency medical services (EMS). The discussion emphasizes the need for caution in changing EMS protocols based on new research and highlights the significance of the NIH stroke scale in assessing stroke severity. Overall, the conversation underscores the importance of evidence-based practice in stroke care and the need for further research before implementing new guidelines.Chapters00:00 Introduction to Stroke Expertise03:09 Exploring the Zodiac Trial09:25 Implications for EMS Practice13:21 Limitations of the Zodiac Study17:24 Research Methodology and Findings26:41 Critical Analysis of Research Implications32:27 Conclusions and Future DirectionsLINK TO THE PAPER: https://jamanetwork.com/journals/jamaneurology/fullarticle/2835054

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