BackTable Urology

Ep. 288 Active Surveillance for Intermediate Risk Prostate Cancer with Dr. Claire de la Calle

03 Feb 2026

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When is active surveillance the right choice for intermediate-risk prostate cancer patients? In this episode of BackTable Urology, Dr. Claire de la Calle, Assistant Professor of Urology at the University of Washington, joins Dr. Ruchika Talwar to unpack how active surveillance has evolved beyond low-risk disease and why select Grade Group 2 patients may be appropriate candidates now with thoughtful patient selection. --- SYNPOSIS The conversation explores emerging tools that can refine surveillance decisions, including PSA density, MRI findings, genomic classifiers, and the growing role of AI-assisted pathology. Dr. de la Calle emphasizes the importance of nuanced patient counseling, acknowledging anxiety and long-term risk while reinforcing that time on active surveillance can be a meaningful win when oncologic outcomes remain comparable to upfront treatment. --- TIMESTAMPS 00:00 - Introduction02:58 - Current Evidence05:03 - Patient Selection Criteria12:11 - Importance of PSA Density and Monitoring Protocols18:12 - Pathology and Genomic Testing32:18 - Future Directions and Research36:33 - Key Takeaways --- RESOURCES ProtecT Trial: Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancerhttps://www.nejm.org/doi/full/10.1056/NEJMoa2214122 Canary PASS Studyhttps://canarypass.org/ Genomic Classifier Performance in Intermediate-Risk Prostate Cancer: Results From NRG Oncology/RTOG 0126 Randomized Phase 3 Trialhttps://pubmed.ncbi.nlm.nih.gov/37137444

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Ep. 288 Active Surveillance for Intermediate Risk Prostate Cancer with Dr. Claire de la Calle

This episode hasn't been transcribed yet

Other episodes from BackTable Urology

Ep. 287 Urothelial Carcinoma: Understanding CTDNA and Precision Medicine with Dr. Amanda Nizam and Dr. Brad McGregor

Ep. 286 Antibiotic Stewardship in Reconstructive Urology with Dr. Joshua Sterling

Ep. 285 Guide to Vaginal Rejuvenation: Myths, Realities, & Medical Insights with Dr. Ariana Smith and Dr. Karyn Eilber

Ep. 213 Dual Physician Households: Managing Parenthood and Careers with Dr. Katie Amin and Dr. Petar Bajic

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